ChemicalBook CAS DataBase List 1-Acetylpiperazine

1-Acetylpiperazine synthesis

9synthesis methods

Product Name:1-Acetylpiperazine
CAS Number:13889-98-0
Molecular formula:C6H12N2O
Molecular Weight:128.17

110-85-0 Synthesis

110-85-0
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108-24-7
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$14.00/250ML

13889-98-0
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Yield:13889-98-0 20%

Reaction Conditions:

in dichloromethane at 0; for 5 h;

Steps:

3.2.7. Synthesis of 1-(Piperazine-1-yl)ethan-1-one (7)
To a stirred mixture of piperazine (C4H10N2) (1.70 g, 19.70 mmol, 2.0 eq.) and dichloromethane(50 mL), acetic anhydride (C4H6O3) (0.94 mL, 9.90 mmol, 1.0 eq.) was added at 0 C and the mixturewas stirred for 5 h. After the reaction was completed, the reaction mixture was quenched with water(15 mL) and extracted with dichloromethane, the organic layer then dried over sodium sulfate (Na2SO4),filtered and concentrated under reduced pressure to aord 7 (0.26 g, 20%) as a colorless solid. 1H-NMR(400 MHz, CDCl3): 2.13 (3H, s), 3.40-3.70 (8H, m). 13C-NMR (100 MHz, CDCl3): 21.3, 41.2 (2C),45.7 (2C), 169.1. HRMS (FAB+) calculated for C6H12N2O [M + H]+: m/z = 129.0949, found 129.1031.

References:

Fawwaz, Muammar;Kinuya, Seigo;Mishiro, Kenji;Nishii, Ryuichi;Ogawa, Kazuma;Sawazaki, Izumi;Shiba, Kazuhiro [Molecules,2020,vol. 25,# 12]

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110-85-0 Synthesis

110-85-0
564 suppliers
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75-36-5 Synthesis