1-(5-ETHYL-THIOPHEN-2-YL)-ETHANONE synthesis
- Product Name:1-(5-ETHYL-THIOPHEN-2-YL)-ETHANONE
- CAS Number:18761-46-1
- Molecular formula:C8H10OS
- Molecular Weight:154.23
Yield:18761-46-1 76%
Reaction Conditions:
with phosphoric acid at 80; for 1 h;
Steps:
1
In a 50 ml three-necked flask, 5 g (44.6 mmol, 1 eq) of 2-ethylthiophene are dissolved in 28 ml of acetic anhydride, 0.5 ml of ortho-phosphoric acid are added and the reaction mixture is then heated for 1 hour at 80° C. The acids are evaporated off under reduced pressure, and the oil obtained is then filtered over a silica patch (eluent: 20% ethyl acetate, 80% heptane) after evaporation of the solvents: 5.2 g of 1-(5-ethylthiophen-2-yl)ethanone are obtained in the form of a brown oil. Yield: 76%.
References:
US2010/144813,2010,A1 Location in patent:Page/Page column 4-5
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