1-(4-Hydroxyphenyl)-1-butanone synthesis
- Product Name:1-(4-Hydroxyphenyl)-1-butanone
- CAS Number:1009-11-6
- Molecular formula:C10H12O2
- Molecular Weight:164.2
141-75-3
351 suppliers
$12.32/25G
108-95-2
761 suppliers
$14.00/25g
1009-11-6
210 suppliers
$11.00/5g
Yield:1009-11-6 98%
Reaction Conditions:
with trifluorormethanesulfonic acid at 0 - 20; for 1 h;regiospecific reaction;Friedel-Crafts acylation;
Steps:
4.3. General procedure of Friedel-Crafts acylation of phenols in TfOH
General procedure: Phenol (0.28 mmol) and acyl chloride (0.28 mmol) were dissolved in TfOH (3 ml) at 0 °C. The reaction mixture was warmed to room temperature for appropriate time in Table 2, then poured into cold water and ethyl acetate. The organic layer was washed with 1 M HCl, saturated NaHCO3, and saturated NaCl, and dried over MgSO4, then filtrated. The filtrate was concentrated and the residue was subjected silica column chromatography to afford acylated products. All spectral data were identical with the literatures.27
References:
Murashige, Ryo;Hayashi, Yuka;Ohmori, Syo;Torii, Ayuko;Aizu, Yoko;Muto, Yasuyuki;Murai, Yuta;Oda, Yuji;Hashimoto, Makoto [Tetrahedron,2011,vol. 67,# 3,p. 641 - 649] Location in patent:experimental part
627-19-0
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$10.00/1g
108-95-2
761 suppliers
$14.00/25g
1009-11-6
210 suppliers
$11.00/5g
72824-04-5
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$6.00/1g
123-08-0
942 suppliers
$5.00/10g
1009-11-6
210 suppliers
$11.00/5g