ChemicalBook CAS DataBase List 1,3-Dimethyl-1,3-diphenylurea

1,3-Dimethyl-1,3-diphenylurea synthesis

12synthesis methods

Product Name: 1,3-Dimethyl-1,3-diphenylurea
CAS Number:611-92-7
Molecular formula:C15H16N2O
Molecular Weight:240.3

A 10 mL Schlenk tube equipped with a magnetic stirring bar was charged with arylcarbamoyl chlorides (0.2 mmol, 1.0 equiv), and KHCO3 (40 mg, 0.4 mmol), and then Pd(PPh3)4 (0.01 mmol, 11.56 mg) were added. Finally, 1,4-dioxane (1.0 mL) was added to the mixture via syringe at room temperature under N2. The tube was sealed and put into a preheated oil bath a 100 °C for 48 h. The mixture was cooled to room temperature, quenched with water (5 mL), and diluted with ethyl acetate (5 mL). The layers were separated, and the aqueous layer was extracted with 2 × 5 mL of ethyl acetate. The combined organic extracts were dried over anhydrous sodium sulfate, filtered, and concentrated in vacuo. The crude product of 1,3-dimethyl-1,3-diphenylurea was then purified by flash chromatography on silica gel (H), eluting with 30-35% ethylacetate/petroleum ether.

4285-42-1
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$100.00/5g

611-92-7
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$40.00/250mg

Yield:611-92-7 95%

Reaction Conditions:

with tetrakis(triphenylphosphine) palladium⁽⁰⁾;potassium hydrogencarbonate in 1,4-dioxane at 100; for 48 h;Catalytic behavior;Schlenk technique;Inert atmosphere;Reagent/catalyst;Solvent;Temperature;

Steps:

2. General Procedures for the Synthesis of Urea Derivatives

General procedure: A 10 mL Schlenk tube equipped with a magnetic stirring bar was charged with arylcarbamoyl chlorides (0.2 mmol, 1.0 equiv), and KHCO₃ (40 mg, 0.4 mmol), and then Pd(PPh₃)₄ (0.01 mmol, 11.56 mg) were added. Finally, 1,4-dioxane (1.0 mL) was added to the mixture via syringe at room temperature under N₂. The tube was sealed and put into a preheated oil bath a 100 °C for 48 h. The mixture was cooled to room temperature, quenched with water (5 mL), and diluted with ethyl acetate (5 mL). The layers were separated, and the aqueous layer was extracted with 2 × 5 mL of ethyl acetate. The combined organic extracts were dried over anhydrous sodium sulfate, filtered, and concentrated in vacuo. The crude product was then purified by flash chromatography on silica gel (H), eluting with 30-35% ethylacetate/petroleum ether. 3. Spectral Data of Urea Derivatives 1,3-Dimethyl-1,3-diphenylurea (2a)³ Yield, 95% (22.8 mg); white solid, mp 120-122 °C .¹H NMR (500 MHz, CDCl₃) δ 7.04 (t, J = 7.8 Hz, 4H), 6.93 (t, J = 7.4 Hz, 2H), 6.79 (d, J = 7.5 Hz, 4H), 3.19 (s, 6H). ¹³C NMR (126 MHz, CDCl₃) δ 160.3, 144.6, 127.6, 124.7, 123.8, 38.3.

References:

Fan, Aihong;Peng, Jinsong;Zhou, Dun;Li, Xiang;Chen, Chunxia [Synthetic Communications,2020,p. 1 - 12] Location in patent:supporting information