1,2,4-Triazolo[4,3-a]pyridin-3(2H)-one synthesis
- Product Name:1,2,4-Triazolo[4,3-a]pyridin-3(2H)-one
- CAS Number:6969-71-7
- Molecular formula:C6H5N3O
- Molecular Weight:135.12
Yield:6969-71-7 75%
Reaction Conditions:
in neat (no solvent) for 0.0138889 h;Microwave irradiation;
Steps:
3.3.1. Preparation of 1,2,4-Triazolo[4,3-a]pyridin-3(2H)-one (1) from 7 under Microwave Conditions (Samsung M182DN; 300 W)
Firstly, 500 mg (4.58 mmol) g of 2-hydrazinopyridine (7) and 275 mg (4.58 mmol) or 550 mg(9.16 mmol) of urea were placed in a conical flask. Reactions were carried out under microwave radiation. The progress of the reaction was monitored by TLC (chloroform-methanol 9:1). After 50 s,15 cm3 of water was added to the mixture, after which the resulting product was filtered o on aBüchner funnel. The product was obtained with eciency 49% in an equimolar reaction and 75%by reaction with a two fold molar excess of urea; Rf = 0.62, HPLC 97.9% (reaction with molar excess),tM 1.95 min.
References:
Jaskowska, Jolanta;Zar eba, Przemys?aw;Sliwa, Pawe?;Pindelska, Edyta;Sata?a, Grzegorz;Majka, Zbigniew [Molecules,2019,vol. 24,# 8,art. no. 1609]
109-04-6
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