1-(1-Methyl-1H-pyrazol-3-yl)-ethanol synthesis
- Product Name:1-(1-Methyl-1H-pyrazol-3-yl)-ethanol
- CAS Number:60031-47-2
- Molecular formula:C6H10N2O
- Molecular Weight:126.16
75-16-1
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27258-32-8
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60031-47-2
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Yield:60031-47-2 44%
Reaction Conditions:
in tetrahydrofuran at 0 - 20;
Steps:
3.2 Step 2) 1-(1-Methyl-1H-pyrazol-3-yl)ethanol
Add 1-methyl-1H-pyrazole-3-carbaldehyde (0.32 g, 2.9 mmol) to a 50 mL two-necked vialAnd tetrahydrofuran (10.0 mL),A solution of 3.0 mol/L methylmagnesium bromide in tetrahydrofuran (1.3 mL, 3.9 mmol) was added dropwise at 0 °C.It was then stirred at room temperature overnight.The reaction was quenched by the addition of a saturated aqueous solution of ammonium chloride, and the residue was dissolved in tetrahydrofurane.filter,The filtrate was dried to give a white solid (0.16 g, 44%).
References:
CN108690016,2018,A Location in patent:Paragraph 0420; 0426; 0427
151049-87-5
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75-07-0
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60031-47-2
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