Zibotentan (ZD4054)
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- $32 - $4733
- Product name: Zibotentan (ZD4054)
- CAS: 186497-07-4
- MF: C19H16N6O4S
- MW: 424.43
- EINECS:
- MDL Number:MFCD09955343
- Synonyms:N-(3-METHOXY-5-METHYLPYRAZIN-2-YL)-2-[4-(1,3,4-OXADIAZOL-2-YL)PHENYL]PYRIDINE-3-SULFONAMIDE;3-Pyridinesulfonamide, N-(3-methoxy-5-methylpyrazinyl)-2-(4-(1,3,4-oxadiazol-2-yl)phenyl)-;Zd 4054;Zd4054;Zibotentan;Zibotentan(ZD4054);N-(3-Methoxy-5-methyl-2-pyrazinyl)-2-[4-(1,3,4-oxadiazol-2-yl)phenyl]-3-pyridinesulfonamide;2-(4-(1,3,4-oxadiazol-2-yl)phenyl)-N-(3-Methoxy-5-Methylpyrazin-2-yl)pyridine-3-sulfonaMide
25 prices
Selected condition：
Brand
- AK Scientific
- Ambeed
- American Custom Chemicals Corporation
- ApexBio Technology
- Cayman Chemical
- ChemScene
- CSNpharm
- DC Chemicals
- Labseeker
- TRC
Package
- 1mg
- 5mg
- 10mg
- 25mg
- 50mg
- 100mg
- 250mg
- 500mg
- 0.5G
- 1G
- ManufacturerAK Scientific
- Product numberX7520
- Product descriptionZibotentan
- Packaging250mg
- Price$482
- Updated2021-12-16
- Buy
- ManufacturerAmbeed
- Product numberA445755
- Product descriptionZibotentan 97%
- Packaging5mg
- Price$109
- Updated2021-12-16
- Buy
- ManufacturerAmbeed
- Product numberA445755
- Product descriptionZibotentan 97%
- Packaging10mg
- Price$185
- Updated2021-12-16
- Buy
- ManufacturerAmbeed
- Product numberA445755
- Product descriptionZibotentan 97%
- Packaging25mg
- Price$314
- Updated2021-12-16
- Buy
- ManufacturerAmbeed
- Product numberA445755
- Product descriptionZibotentan 97%
- Packaging250mg
- Price$1120
- Updated2021-12-16
- Buy
- ManufacturerAmerican Custom Chemicals Corporation
- Product numberAPI0005352
- Product descriptionZD-4054 95.00%
- Packaging5MG
- Price$330
- Updated2021-12-16
- Buy
- ManufacturerAmerican Custom Chemicals Corporation
- Product numberAPI0005352
- Product descriptionZD-4054 95.00%
- Packaging0.5G
- Price$2744.5
- Updated2021-12-16
- Buy
- ManufacturerAmerican Custom Chemicals Corporation
- Product numberAPI0005352
- Product descriptionZD-4054 95.00%
- Packaging1G
- Price$4036.73
- Updated2021-12-16
- Buy
- ManufacturerApexBio Technology
- Product numberA5489
- Product descriptionZibotentan(ZD4054)
- Packaging5mg
- Price$126
- Updated2021-12-16
- Buy
- ManufacturerCayman Chemical
- Product number23702
- Product descriptionZibotentan ≥98%
- Packaging1mg
- Price$32
- Updated2024-03-01
- Buy
- ManufacturerCayman Chemical
- Product number23702
- Product descriptionZibotentan ≥98%
- Packaging5mg
- Price$93
- Updated2024-03-01
- Buy
- ManufacturerCayman Chemical
- Product number23702
- Product descriptionZibotentan ≥98%
- Packaging10mg
- Price$169
- Updated2024-03-01
- Buy
- ManufacturerCayman Chemical
- Product number23702
- Product descriptionZibotentan ≥98%
- Packaging25mg
- Price$381
- Updated2024-03-01
- Buy
- ManufacturerChemScene
- Product numberCS-0492
- Product descriptionZibotentan 99.66%
- Packaging5mg
- Price$168
- Updated2021-12-16
- Buy
- ManufacturerChemScene
- Product numberCS-0492
- Product descriptionZibotentan 99.66%
- Packaging10mg
- Price$312
- Updated2021-12-16
- Buy
- ManufacturerChemScene
- Product numberCS-0492
- Product descriptionZibotentan 99.66%
- Packaging50mg
- Price$960
- Updated2021-12-16
- Buy
| Manufacturer | Product number | Product description | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|
| AK Scientific | X7520 | Zibotentan | 250mg | $482 | 2021-12-16 | Buy |
| Ambeed | A445755 | Zibotentan 97% | 5mg | $109 | 2021-12-16 | Buy |
| Ambeed | A445755 | Zibotentan 97% | 10mg | $185 | 2021-12-16 | Buy |
| Ambeed | A445755 | Zibotentan 97% | 25mg | $314 | 2021-12-16 | Buy |
| Ambeed | A445755 | Zibotentan 97% | 250mg | $1120 | 2021-12-16 | Buy |
| American Custom Chemicals Corporation | API0005352 | ZD-4054 95.00% | 5MG | $330 | 2021-12-16 | Buy |
| American Custom Chemicals Corporation | API0005352 | ZD-4054 95.00% | 0.5G | $2744.5 | 2021-12-16 | Buy |
| American Custom Chemicals Corporation | API0005352 | ZD-4054 95.00% | 1G | $4036.73 | 2021-12-16 | Buy |
| ApexBio Technology | A5489 | Zibotentan(ZD4054) | 5mg | $126 | 2021-12-16 | Buy |
| Cayman Chemical | 23702 | Zibotentan ≥98% | 1mg | $32 | 2024-03-01 | Buy |
| Cayman Chemical | 23702 | Zibotentan ≥98% | 5mg | $93 | 2024-03-01 | Buy |
| Cayman Chemical | 23702 | Zibotentan ≥98% | 10mg | $169 | 2024-03-01 | Buy |
| Cayman Chemical | 23702 | Zibotentan ≥98% | 25mg | $381 | 2024-03-01 | Buy |
| ChemScene | CS-0492 | Zibotentan 99.66% | 5mg | $168 | 2021-12-16 | Buy |
| ChemScene | CS-0492 | Zibotentan 99.66% | 10mg | $312 | 2021-12-16 | Buy |
| ChemScene | CS-0492 | Zibotentan 99.66% | 50mg | $960 | 2021-12-16 | Buy |
Properties
Melting point :239 - 241°C
Boiling point :637.0±65.0 °C(Predicted)
Density :1.422
storage temp. :Sealed in dry,Store in freezer, under -20°C
solubility :DMSO (Sparingly), Methanol (Slightly)
form :Solid
pka :5.62±0.40(Predicted)
color :White to Off-White
Boiling point :637.0±65.0 °C(Predicted)
Density :1.422
storage temp. :Sealed in dry,Store in freezer, under -20°C
solubility :DMSO (Sparingly), Methanol (Slightly)
form :Solid
pka :5.62±0.40(Predicted)
color :White to Off-White
Safety Information
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| Signal word: | Warning | ||||||||||||||
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Description
Zibotentan is a selective antagonist of the endothelin (ET) receptor type A (IC50s = 21 and >10,000 nM for human recombinant ETA and ETB, respectively). It inhibits growth of HEY, OVCA 433, SKOV3, and A2780 cells induced by endothelin 1 (ET-1; ) in vitro. Zibotentan reduces ET-1-induced expression of MMP-2, MMP-9, VEGF, COX-1 and COX-2, mediators of cell invasion and angiogenesis, in HEY cells. In vivo, zibotentan (10-50 mg/kg per day) reduces tumor growth in an HEY mouse xenograft model in a dose-dependent manner. Formulations containing zibotentan are under clinical investigation for the treatment of ovarian and castration-resistant prostate cancers.Related product price
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