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ChemicalBook >> CAS DataBase List >> Siremadlin

Siremadlin

Siremadlin price.
  • $70 - $2500
  • Product name: Siremadlin
  • CAS: 1448867-41-1
  • MF: C26H24Cl2N6O4
  • MW: 555.41
  • EINECS:
  • MDL Number:MFCD30502893
  • Synonyms:(6S)-5-(5-chloro-1,2-dihydro-1-methyl-2-oxo-3-pyridinyl)-6-(4-chlorophenyl)-2-(2,4-dimethoxy-5-pyrimidinyl)-5,6-dihydro-1-(1-methylethyl)-Pyrrolo[3,4-d]imidazol-4(1H)-one;Pyrrolo[3,4-d]imidazol-4(1H)-one, 5-(5-chloro-1,2-dihydro-1-methyl-2-oxo-3-pyridinyl)-6-(4-chlorophenyl)-2-(2,4-dimethoxy-5-pyrimidinyl)-5,6-dihydro-1-(1-methylethyl)-, (6S)-;Siremadlin (NVP-HDM201);NVP-HDM201;CS-2613;CS-2787;HDM201; HDM 201; HDM-201; NVP-HDM201; NVP-HDM-201; NVP-HDM 201;(S)-5-(5-chloro-1-methyl-2-oxo-1,2-dihydropyridin-3-yl)-6-(4-chlorophenyl)-2-(2,4-dimethoxypyrimidin-5-yl)-1-isopropyl-5,6-dihydropyrrolo[3,4-d]imidazol-4(1H)-one
10 prices
Selected condition：
Brand
  • AK Scientific
  • Biosynth Carbosynth
  • ChemScene
  • DC Chemicals
Package
  • 1mg
  • 5mg
  • 10mg
  • 50mg
  • 100mg
  • 250mg
  • 1g
  • ManufacturerAK Scientific
  • Product number1697DV
  • Product descriptionSiremadlin
  • Packaging10mg
  • Price$286
  • Updated2021-12-16
  • Buy
  • ManufacturerBiosynth Carbosynth
  • Product numberBH166424
  • Product descriptionNVP HDM 201
  • Packaging10mg
  • Price$175
  • Updated2021-12-16
  • Buy
  • ManufacturerBiosynth Carbosynth
  • Product numberBH166424
  • Product descriptionNVP HDM 201
  • Packaging50mg
  • Price$612.5
  • Updated2021-12-16
  • Buy
  • ManufacturerChemScene
  • Product numberCS-7654
  • Product descriptionSiremadlin 99.82%
  • Packaging100mg
  • Price$1100
  • Updated2021-12-16
  • Buy
  • ManufacturerChemScene
  • Product numberCS-7654
  • Product descriptionSiremadlin 99.82%
  • Packaging50mg
  • Price$650
  • Updated2021-12-16
  • Buy
  • ManufacturerChemScene
  • Product numberCS-7654
  • Product descriptionSiremadlin 99.82%
  • Packaging10mg
  • Price$220
  • Updated2021-12-16
  • Buy
  • ManufacturerChemScene
  • Product numberCS-7654
  • Product descriptionSiremadlin 99.82%
  • Packaging5mg
  • Price$150
  • Updated2021-12-16
  • Buy
  • ManufacturerChemScene
  • Product numberCS-7654
  • Product descriptionSiremadlin 99.82%
  • Packaging1mg
  • Price$70
  • Updated2021-12-16
  • Buy
  • ManufacturerDC Chemicals
  • Product numberDC10613
  • Product descriptionSiremadlin(NVP-HDM201) >98%
  • Packaging250mg
  • Price$1200
  • Updated2021-12-16
  • Buy
  • ManufacturerDC Chemicals
  • Product numberDC10613
  • Product descriptionSiremadlin(NVP-HDM201) >98%
  • Packaging1g
  • Price$2500
  • Updated2021-12-16
  • Buy
Manufacturer Product number Product description Packaging Price Updated Buy
AK Scientific 1697DV Siremadlin 10mg $286 2021-12-16 Buy
Biosynth Carbosynth BH166424 NVP HDM 201 10mg $175 2021-12-16 Buy
Biosynth Carbosynth BH166424 NVP HDM 201 50mg $612.5 2021-12-16 Buy
ChemScene CS-7654 Siremadlin 99.82% 100mg $1100 2021-12-16 Buy
ChemScene CS-7654 Siremadlin 99.82% 50mg $650 2021-12-16 Buy
ChemScene CS-7654 Siremadlin 99.82% 10mg $220 2021-12-16 Buy
ChemScene CS-7654 Siremadlin 99.82% 5mg $150 2021-12-16 Buy
ChemScene CS-7654 Siremadlin 99.82% 1mg $70 2021-12-16 Buy
DC Chemicals DC10613 Siremadlin(NVP-HDM201) >98% 250mg $1200 2021-12-16 Buy
DC Chemicals DC10613 Siremadlin(NVP-HDM201) >98% 1g $2500 2021-12-16 Buy

Properties

Boiling point :736.5±70.0 °C(Predicted)
Density :1.47±0.1 g/cm3(Predicted)
storage temp. :Store at -20°C
solubility :DMSO : ≥ 56.75 mg/mL (102.18 mM)
form :Solid
pka :1.33±0.29(Predicted)
color :White to off-white

Safety Information

Symbol(GHS): GHS hazard pictograms
Signal word: Warning
Hazard statements:
Code Hazard statements Hazard class Category Signal word Pictogram P-Codes
H302 Harmful if swallowed Acute toxicity,oral Category 4 Warning GHS hazard pictograms P264, P270, P301+P312, P330, P501
H315 Causes skin irritation Skin corrosion/irritation Category 2 Warning GHS hazard pictograms P264, P280, P302+P352, P321,P332+P313, P362
H319 Causes serious eye irritation Serious eye damage/eye irritation Category 2A Warning GHS hazard pictograms P264, P280, P305+P351+P338,P337+P313P
H335 May cause respiratory irritation Specific target organ toxicity, single exposure;Respiratory tract irritation Category 3 Warning GHS hazard pictograms
Precautionary statements:
P261 Avoid breathing dust/fume/gas/mist/vapours/spray.
P280 Wear protective gloves/protective clothing/eye protection/face protection.
P301+P312 IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.
P302+P352 IF ON SKIN: wash with plenty of soap and water.
P305+P351+P338 IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

Description

Siremadlin is an oral biologic agent that is a selective inhibitor of the p53-MDM2 interaction and is being investigated for the treatment of patients with myeloid malignancies after showing single agent activity in preclinical studies.

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