Simeprevir sodium
- $44 - $638
- Product name: Simeprevir sodium
- CAS: 1241946-89-3
- MF: C38H47N5O7S2.x(Na)
- MW: 773.94
- EINECS:-0
- MDL Number:MFCD30724946
- Synonyms:Simeprevir sodium;TMC 435 sodium salt;Olysio
4 prices
Selected condition:
Brand
- Cayman Chemical
Package
- 1mg
- 5mg
- 10mg
- 25mg
- ManufacturerCayman Chemical
- Product number22144
- Product descriptionSimeprevir (sodium salt)
- Packaging1mg
- Price$44
- Updated2024-03-01
- Buy
- ManufacturerCayman Chemical
- Product number22144
- Product descriptionSimeprevir (sodium salt)
- Packaging5mg
- Price$151
- Updated2024-03-01
- Buy
- ManufacturerCayman Chemical
- Product number22144
- Product descriptionSimeprevir (sodium salt)
- Packaging10mg
- Price$278
- Updated2024-03-01
- Buy
- ManufacturerCayman Chemical
- Product number22144
- Product descriptionSimeprevir (sodium salt)
- Packaging25mg
- Price$638
- Updated2024-03-01
- Buy
Manufacturer | Product number | Product description | Packaging | Price | Updated | Buy |
---|---|---|---|---|---|---|
Cayman Chemical | 22144 | Simeprevir (sodium salt) | 1mg | $44 | 2024-03-01 | Buy |
Cayman Chemical | 22144 | Simeprevir (sodium salt) | 5mg | $151 | 2024-03-01 | Buy |
Cayman Chemical | 22144 | Simeprevir (sodium salt) | 10mg | $278 | 2024-03-01 | Buy |
Cayman Chemical | 22144 | Simeprevir (sodium salt) | 25mg | $638 | 2024-03-01 | Buy |
Properties
storage temp. :Store at -20°C
solubility :DMSO:30.0(Max Conc. mg/mL);38.86(Max Conc. mM)
DMSO:PBS (pH 7.2) (1:2):0.33(Max Conc. mg/mL);0.43(Max Conc. mM)
DMF:30.0(Max Conc. mg/mL);38.86(Max Conc. mM) form :A crystalline solid
solubility :DMSO:30.0(Max Conc. mg/mL);38.86(Max Conc. mM)
DMSO:PBS (pH 7.2) (1:2):0.33(Max Conc. mg/mL);0.43(Max Conc. mM)
DMF:30.0(Max Conc. mg/mL);38.86(Max Conc. mM) form :A crystalline solid
Safety Information
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Description
Simeprevir is an orally bioavailable and potent inhibitor of the hepatitis C virus (HCV) nonstructural protein 3/4A (NS3/4A) protease (Ki = 0.36 nM), a serine protease essential for HCV replication. It inhibits HCV viral replication with an EC50 value of 7.8 nM in Huh7 replicon cells using a luciferase-based assay. Simeprevir is effective against the HCV genotypes 1a and 1b in biochemical assays. In Huh7 replicon cells, it is synergistically effective when used in combination with IFN-α or NM-107 and has an additive effect when used with ribavirin . Formulations containing simeprevir have been used, alone or in combination with pegylated IFN-α and ribavirin, for the treatment of HCV.More related product prices
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