Pracinostat
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- $28 - $14860
- Product name: Pracinostat
- CAS: 929016-96-6
- MF: C20H30N4O2
- MW: 358.48
- EINECS:
- MDL Number:MFCD17215206
- Synonyms:Pracinostat (SB939);SB939;(2E)-3-[2-Butyl-1-[2-(diethylaMino)ethyl]-1H-benziMidazol-5-yl]-N-hydroxy-2-propenaMide;(2E)-3-[2-Butyl-1-[2-(diethylaMino)ethyl]-1H-benziMidazol-5-yl]-N-hydroxyacrylaMide;(E)-3-[2-Butyl-1-(2-diethylaMinoethyl)-1H-benziMidazol-5-yl]-N-hydroxy-2-propenaMide;KaeMpferol 3-O-β-D-(6-E-p-CouMaroylglucoside);Pracinostat;2-Propenamide, 3-[2-butyl-1-[2-(diethylamino)ethyl]-1H-benzimidazol-5-yl]-N-hydroxy-, (2E)-
41 prices
Selected condition：
Brand
- AK Scientific
- American Custom Chemicals Corporation
- ApexBio Technology
- Arctom
- Axon Medchem
- Biorbyt Ltd
- Biosynth Carbosynth
- Cayman Chemical
- Chemenu
- ChemScene
- Crysdot
- DC Chemicals
- Labseeker
- Medical Isotopes, Inc.
- TRC
- Usbiological
Package
- 10mM(in 1mL DMSO)
- 1mg
- 1unit
- 2mg
- 5MG
- 10MG
- 25mg
- 50MG
- 100MG
- 250mg
- 1G
- 1000mg
- ManufacturerAK Scientific
- Product numberJ97244
- Product descriptionPracinostat
- Packaging250mg
- Price$270
- Updated2021-12-16
- Buy
- ManufacturerAK Scientific
- Product numberX7533
- Product descriptionPracinostat
- Packaging1mg
- Price$49
- Updated2021-12-16
- Buy
- ManufacturerAmerican Custom Chemicals Corporation
- Product numberINB0000895
- Product descriptionSB-939 99.00%
- Packaging5MG
- Price$498
- Updated2021-12-16
- Buy
- ManufacturerAmerican Custom Chemicals Corporation
- Product numberINB0000895
- Product descriptionSB-939 99.00%
- Packaging10MG
- Price$579
- Updated2021-12-16
- Buy
- ManufacturerAmerican Custom Chemicals Corporation
- Product numberINB0000895
- Product descriptionSB-939 99.00%
- Packaging50MG
- Price$1123
- Updated2021-12-16
- Buy
- ManufacturerAmerican Custom Chemicals Corporation
- Product numberINB0000895
- Product descriptionSB-939 99.00%
- Packaging100MG
- Price$1846
- Updated2021-12-16
- Buy
- ManufacturerAmerican Custom Chemicals Corporation
- Product numberINB0000895
- Product descriptionSB-939 99.00%
- Packaging1G
- Price$14860
- Updated2021-12-16
- Buy
- ManufacturerApexBio Technology
- Product numberA4095
- Product descriptionPracinostat(SB939)
- Packaging1unit
- Price$28
- Updated2021-12-16
- Buy
- ManufacturerApexBio Technology
- Product numberA4095
- Product descriptionPracinostat(SB939)
- Packaging5mg
- Price$115
- Updated2021-12-16
- Buy
- ManufacturerApexBio Technology
- Product numberA4095
- Product descriptionPracinostat(SB939)
- Packaging10mM(in 1mL DMSO)
- Price$127
- Updated2021-12-16
- Buy
- ManufacturerApexBio Technology
- Product numberA4095
- Product descriptionPracinostat(SB939)
- Packaging10mg
- Price$210
- Updated2021-12-16
- Buy
- ManufacturerApexBio Technology
- Product numberA4095
- Product descriptionPracinostat(SB939)
- Packaging50mg
- Price$610
- Updated2021-12-16
- Buy
- ManufacturerArctom
- Product numberCFN60428
- Product descriptionPracinostat(SB939) ≥98%
- Packaging10mg
- Price$308
- Updated2021-12-16
- Buy
- ManufacturerAxon Medchem
- Product numberAxon1777
- Product descriptionSB939-Pracinostat 99%
- Packaging25mg
- Price$357.5
- Updated2021-12-16
- Buy
- ManufacturerBiorbyt Ltd
- Product numberorb181135
- Product descriptionPracinostat(SB939) >98%
- Packaging100mg
- Price$615.4
- Updated2021-12-16
- Buy
- ManufacturerBiorbyt Ltd
- Product numberorb181135
- Product descriptionPracinostat(SB939) >98%
- Packaging250mg
- Price$1208.7
- Updated2021-12-16
- Buy
| Manufacturer | Product number | Product description | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|
| AK Scientific | J97244 | Pracinostat | 250mg | $270 | 2021-12-16 | Buy |
| AK Scientific | X7533 | Pracinostat | 1mg | $49 | 2021-12-16 | Buy |
| American Custom Chemicals Corporation | INB0000895 | SB-939 99.00% | 5MG | $498 | 2021-12-16 | Buy |
| American Custom Chemicals Corporation | INB0000895 | SB-939 99.00% | 10MG | $579 | 2021-12-16 | Buy |
| American Custom Chemicals Corporation | INB0000895 | SB-939 99.00% | 50MG | $1123 | 2021-12-16 | Buy |
| American Custom Chemicals Corporation | INB0000895 | SB-939 99.00% | 100MG | $1846 | 2021-12-16 | Buy |
| American Custom Chemicals Corporation | INB0000895 | SB-939 99.00% | 1G | $14860 | 2021-12-16 | Buy |
| ApexBio Technology | A4095 | Pracinostat(SB939) | 1unit | $28 | 2021-12-16 | Buy |
| ApexBio Technology | A4095 | Pracinostat(SB939) | 5mg | $115 | 2021-12-16 | Buy |
| ApexBio Technology | A4095 | Pracinostat(SB939) | 10mM(in 1mL DMSO) | $127 | 2021-12-16 | Buy |
| ApexBio Technology | A4095 | Pracinostat(SB939) | 10mg | $210 | 2021-12-16 | Buy |
| ApexBio Technology | A4095 | Pracinostat(SB939) | 50mg | $610 | 2021-12-16 | Buy |
| Arctom | CFN60428 | Pracinostat(SB939) ≥98% | 10mg | $308 | 2021-12-16 | Buy |
| Axon Medchem | Axon1777 | SB939-Pracinostat 99% | 25mg | $357.5 | 2021-12-16 | Buy |
| Biorbyt Ltd | orb181135 | Pracinostat(SB939) >98% | 100mg | $615.4 | 2021-12-16 | Buy |
| Biorbyt Ltd | orb181135 | Pracinostat(SB939) >98% | 250mg | $1208.7 | 2021-12-16 | Buy |
Properties
Density :1.11
storage temp. :Store at -20°C
solubility :insoluble in H2O; ≥11.4 mg/mL in DMSO; ≥24.8 mg/mL in EtOH with ultrasonic
form :solid
pka :8.67±0.23(Predicted)
color :White to light brown
storage temp. :Store at -20°C
solubility :insoluble in H2O; ≥11.4 mg/mL in DMSO; ≥24.8 mg/mL in EtOH with ultrasonic
form :solid
pka :8.67±0.23(Predicted)
color :White to light brown
Safety Information
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| Signal word: | Warning | ||||||||||||||||||||||||||||||
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Description
Inhibition of histone deacetylases (HDACs) leads to accumulation of acetylated histones, resulting in a variety of cell type-dependent responses including apoptosis, necrosis, differentiation, cell survival, inhibition of proliferation, and cytostasis. SB939 is an HDAC inhibitor that displays an IC50 value of 77 nM in an in vitro HDAC1 activity assay and prevents proliferation of ovarian (A2780), colon (COLO 205 and HCT-116), and prostate cancer (PC-3) cell lines at IC50 values of 0.48, 0.56, 0.48, and 0.34 μM, respectively. SB939 is a pan-HDAC inhibitor binding all HDAC isozymes with similar affinity (Kis = 16-28 nM) with the exception of HDAC6 and 7 (Kis = 247 and 104 nM, respectively). SB939 demonstrates good bioavailability in vivo and significantly inhibits tumor growth in various xenograft mouse models at doses ranging from 25-100 mg/kg. It is being evaluated in phase I and phase II clinical trials in both hematological and solid tumor patients.More related product prices
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