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ChemicalBook >> CAS DataBase List >> GSK583

GSK583

GSK583 price.
  • $44 - $613
  • Product name: GSK583
  • CAS: 1346547-00-9
  • MF: C20H19FN4O2S
  • MW: 398.45
  • EINECS:-0
  • MDL Number:MFCD30343846
  • Synonyms:GSK583;SK583;6-[(1,1-Dimethylethyl)sulfonyl]-N-(5-fluoro-1H-indazol-3-yl)-4-quinolinamine;RIP2 kinase inhibitor 583;CS-2216;GSK583, >98%;GSK-583;GSK 583;4-Quinolinamine, 6-[(1,1-dimethylethyl)sulfonyl]-N-(5-fluoro-1H-indazol-3-yl)-
17 prices
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  • Ambeed
  • Biosynth Carbosynth
  • Cayman Chemical
  • Crysdot
  • DC Chemicals
  • Tocris
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Package
  • 5
  • 5mg
  • 10mg
  • 25
  • 25mg
  • 50mg
  • 100mg
  • 250mg
  • ManufacturerAmbeed
  • Product numberA341470
  • Product description6-(tert-Butylsulfonyl)-N-(5-fluoro-1H-indazol-3-yl)quinolin-4-amine 98+%
  • Packaging5mg
  • Price$91
  • Updated2021-12-16
  • Buy
  • ManufacturerAmbeed
  • Product numberA341470
  • Product description6-(tert-Butylsulfonyl)-N-(5-fluoro-1H-indazol-3-yl)quinolin-4-amine 98+%
  • Packaging10mg
  • Price$119
  • Updated2021-12-16
  • Buy
  • ManufacturerAmbeed
  • Product numberA341470
  • Product description6-(tert-Butylsulfonyl)-N-(5-fluoro-1H-indazol-3-yl)quinolin-4-amine 98+%
  • Packaging25mg
  • Price$155
  • Updated2021-12-16
  • Buy
  • ManufacturerAmbeed
  • Product numberA341470
  • Product description6-(tert-Butylsulfonyl)-N-(5-fluoro-1H-indazol-3-yl)quinolin-4-amine 98+%
  • Packaging50mg
  • Price$202
  • Updated2021-12-16
  • Buy
  • ManufacturerBiosynth Carbosynth
  • Product numberBG163813
  • Product descriptionGSK 583 NEW
  • Packaging10mg
  • Price$125
  • Updated2021-12-16
  • Buy
  • ManufacturerBiosynth Carbosynth
  • Product numberBG163813
  • Product descriptionGSK 583 NEW
  • Packaging50mg
  • Price$437.5
  • Updated2021-12-16
  • Buy
  • ManufacturerCayman Chemical
  • Product number19739
  • Product descriptionGSK583 ≥98%
  • Packaging10mg
  • Price$44
  • Updated2024-03-01
  • Buy
  • ManufacturerCayman Chemical
  • Product number19739
  • Product descriptionGSK583 ≥98%
  • Packaging25mg
  • Price$104
  • Updated2024-03-01
  • Buy
  • ManufacturerCayman Chemical
  • Product number19739
  • Product descriptionGSK583 ≥98%
  • Packaging50mg
  • Price$183
  • Updated2024-03-01
  • Buy
  • ManufacturerCayman Chemical
  • Product number19739
  • Product descriptionGSK583 ≥98%
  • Packaging100mg
  • Price$341
  • Updated2024-03-01
  • Buy
  • ManufacturerCayman Chemical
  • Product number19739
  • Product descriptionGSK583 ≥98%
  • Packaging250mg
  • Price$613
  • Updated2021-12-16
  • Buy
  • ManufacturerCrysdot
  • Product numberCD31003800
  • Product descriptionGSK583 98+%
  • Packaging50mg
  • Price$155
  • Updated2021-12-16
  • Buy
  • ManufacturerCrysdot
  • Product numberCD31003800
  • Product descriptionGSK583 98+%
  • Packaging100mg
  • Price$265
  • Updated2021-12-16
  • Buy
  • ManufacturerDC Chemicals
  • Product numberDC9733
  • Product descriptionGSK583 >98%
  • Packaging100mg
  • Price$550
  • Updated2021-12-16
  • Buy
  • ManufacturerTocris
  • Product number6480
  • Product descriptionGSK583 ≥98%(HPLC)
  • Packaging5
  • Price$74
  • Updated2021-12-16
  • Buy
  • ManufacturerTocris
  • Product number6480
  • Product descriptionGSK583 ≥98%(HPLC)
  • Packaging25
  • Price$290
  • Updated2021-12-16
  • Buy
Manufacturer Product number Product description Packaging Price Updated Buy
Ambeed A341470 6-(tert-Butylsulfonyl)-N-(5-fluoro-1H-indazol-3-yl)quinolin-4-amine 98+% 5mg $91 2021-12-16 Buy
Ambeed A341470 6-(tert-Butylsulfonyl)-N-(5-fluoro-1H-indazol-3-yl)quinolin-4-amine 98+% 10mg $119 2021-12-16 Buy
Ambeed A341470 6-(tert-Butylsulfonyl)-N-(5-fluoro-1H-indazol-3-yl)quinolin-4-amine 98+% 25mg $155 2021-12-16 Buy
Ambeed A341470 6-(tert-Butylsulfonyl)-N-(5-fluoro-1H-indazol-3-yl)quinolin-4-amine 98+% 50mg $202 2021-12-16 Buy
Biosynth Carbosynth BG163813 GSK 583 NEW 10mg $125 2021-12-16 Buy
Biosynth Carbosynth BG163813 GSK 583 NEW 50mg $437.5 2021-12-16 Buy
Cayman Chemical 19739 GSK583 ≥98% 10mg $44 2024-03-01 Buy
Cayman Chemical 19739 GSK583 ≥98% 25mg $104 2024-03-01 Buy
Cayman Chemical 19739 GSK583 ≥98% 50mg $183 2024-03-01 Buy
Cayman Chemical 19739 GSK583 ≥98% 100mg $341 2024-03-01 Buy
Cayman Chemical 19739 GSK583 ≥98% 250mg $613 2021-12-16 Buy
Crysdot CD31003800 GSK583 98+% 50mg $155 2021-12-16 Buy
Crysdot CD31003800 GSK583 98+% 100mg $265 2021-12-16 Buy
DC Chemicals DC9733 GSK583 >98% 100mg $550 2021-12-16 Buy
Tocris 6480 GSK583 ≥98%(HPLC) 5 $74 2021-12-16 Buy
Tocris 6480 GSK583 ≥98%(HPLC) 25 $290 2021-12-16 Buy

Properties

Boiling point :652.9±55.0 °C(Predicted)
Density :1.402±0.06 g/cm3(Predicted)
storage temp. :under inert gas (nitrogen or Argon) at 2–8 °C
solubility :Soluble in DMSO (up to at least 25 mg/ml).
form :solid
pka :12.59±0.40(Predicted)
color :Pale yellow
Stability :Stable for 1 year from date of purchase as supplied. Solutions in DMSO may be stored at -20° for up to 1 month.

Safety Information

Symbol(GHS): GHS hazard pictograms
Signal word: Warning
Hazard statements:
Code Hazard statements Hazard class Category Signal word Pictogram P-Codes
H302 Harmful if swallowed Acute toxicity,oral Category 4 Warning GHS hazard pictograms P264, P270, P301+P312, P330, P501
H315 Causes skin irritation Skin corrosion/irritation Category 2 Warning GHS hazard pictograms P264, P280, P302+P352, P321,P332+P313, P362
H319 Causes serious eye irritation Serious eye damage/eye irritation Category 2A Warning GHS hazard pictograms P264, P280, P305+P351+P338,P337+P313P
H335 May cause respiratory irritation Specific target organ toxicity, single exposure;Respiratory tract irritation Category 3 Warning GHS hazard pictograms
Precautionary statements:
P261 Avoid breathing dust/fume/gas/mist/vapours/spray.
P305+P351+P338 IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

Description

GSK583 (1346547-00-9) is a highly selective and potent inhibitor of RIP2 kinase, IC50?= 5 nM human and IC50?= 2 nM rat.1?It also potently inhibits isolated RIP3 kinase (IC50?= 5 nM) but is inactive against RIP3 in cellular assays due to a very low KM,ATP. GSK583 blocks NOD2 signaling by interfering with XIAP-RIP2 binding resulting in decreased cytokine and chemokine production.1,2