BV6
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- $44 - $2800
- Product name: BV6
- CAS: 1001600-56-1
- MF: C70H96N10O8
- MW: 1205.57
- EINECS:
- MDL Number:MFCD28168021
- Synonyms:4,4'-(1,6-Hexanediyl)bis[N-methyl-L-alanyl-(2S)-2-cyclohexylglycyl-L-prolyl-beta-phenyl-L-phenylalaninamide;BV6;N,N'-(hexane-1,6-diyl)bis(1-{(2S)-2-cyclohexyl-2-[(N-methyl-L-alanyl)amino]acetyl}-L-prolyl-beta-phenyl-L-phenylalaninamide):trifluoroacetic acid(1:x);CHEBI:47924;CHEBI:47924; BV-6 BV 6;CS-2877;CS-1501;BV-6;BV6
21 prices
Selected condition：
Brand
- AK Scientific
- Ambeed
- ApexBio Technology
- Arctom
- Cayman Chemical
- Crysdot
- DC Chemicals
- TRC
Package
- 1mg
- 2mg
- 5mg
- 10mg
- 25mg
- 50mg
- 10mM(in 1mL DMSO)
- 100mg
- 250mg
- 1g
- ManufacturerAK Scientific
- Product number2291AH
- Product descriptionBV6
- Packaging10mg
- Price$455
- Updated2021-12-16
- Buy
- ManufacturerAmbeed
- Product numberA357114
- Product descriptionBV-6free 98+%
- Packaging2mg
- Price$52
- Updated2021-12-16
- Buy
- ManufacturerAmbeed
- Product numberA357114
- Product descriptionBV-6free 98+%
- Packaging5mg
- Price$74
- Updated2021-12-16
- Buy
- ManufacturerAmbeed
- Product numberA357114
- Product descriptionBV-6free 98+%
- Packaging10mg
- Price$122
- Updated2021-12-16
- Buy
- ManufacturerAmbeed
- Product numberA357114
- Product descriptionBV-6free 98+%
- Packaging50mg
- Price$393
- Updated2021-12-16
- Buy
- ManufacturerAmbeed
- Product numberA357114
- Product descriptionBV-6free 98+%
- Packaging100mg
- Price$674
- Updated2021-12-16
- Buy
- ManufacturerAmbeed
- Product numberA357114
- Product descriptionBV-6free 98+%
- Packaging250mg
- Price$1415
- Updated2021-12-16
- Buy
- ManufacturerApexBio Technology
- Product numberB4653
- Product descriptionBV6
- Packaging5mg
- Price$105
- Updated2021-12-16
- Buy
- ManufacturerApexBio Technology
- Product numberB4653
- Product descriptionBV6
- Packaging10mM(in 1mL DMSO)
- Price$290
- Updated2021-12-16
- Buy
- ManufacturerApexBio Technology
- Product numberB4653
- Product descriptionBV6
- Packaging25mg
- Price$340
- Updated2021-12-16
- Buy
- ManufacturerApexBio Technology
- Product numberB4653
- Product descriptionBV6
- Packaging100mg
- Price$700
- Updated2021-12-16
- Buy
- ManufacturerArctom
- Product numberCFN60244
- Product descriptionBV-6
- Packaging10mg
- Price$358
- Updated2021-12-16
- Buy
- ManufacturerCayman Chemical
- Product number28830
- Product descriptionBV6
- Packaging1mg
- Price$44
- Updated2024-03-01
- Buy
- ManufacturerCayman Chemical
- Product number28830
- Product descriptionBV6
- Packaging5mg
- Price$172
- Updated2024-03-01
- Buy
- ManufacturerCayman Chemical
- Product number28830
- Product descriptionBV6
- Packaging10mg
- Price$321
- Updated2024-03-01
- Buy
- ManufacturerCrysdot
- Product numberCD31004893
- Product descriptionBV6 98+%
- Packaging50mg
- Price$666
- Updated2021-12-16
- Buy
| Manufacturer | Product number | Product description | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|
| AK Scientific | 2291AH | BV6 | 10mg | $455 | 2021-12-16 | Buy |
| Ambeed | A357114 | BV-6free 98+% | 2mg | $52 | 2021-12-16 | Buy |
| Ambeed | A357114 | BV-6free 98+% | 5mg | $74 | 2021-12-16 | Buy |
| Ambeed | A357114 | BV-6free 98+% | 10mg | $122 | 2021-12-16 | Buy |
| Ambeed | A357114 | BV-6free 98+% | 50mg | $393 | 2021-12-16 | Buy |
| Ambeed | A357114 | BV-6free 98+% | 100mg | $674 | 2021-12-16 | Buy |
| Ambeed | A357114 | BV-6free 98+% | 250mg | $1415 | 2021-12-16 | Buy |
| ApexBio Technology | B4653 | BV6 | 5mg | $105 | 2021-12-16 | Buy |
| ApexBio Technology | B4653 | BV6 | 10mM(in 1mL DMSO) | $290 | 2021-12-16 | Buy |
| ApexBio Technology | B4653 | BV6 | 25mg | $340 | 2021-12-16 | Buy |
| ApexBio Technology | B4653 | BV6 | 100mg | $700 | 2021-12-16 | Buy |
| Arctom | CFN60244 | BV-6 | 10mg | $358 | 2021-12-16 | Buy |
| Cayman Chemical | 28830 | BV6 | 1mg | $44 | 2024-03-01 | Buy |
| Cayman Chemical | 28830 | BV6 | 5mg | $172 | 2024-03-01 | Buy |
| Cayman Chemical | 28830 | BV6 | 10mg | $321 | 2024-03-01 | Buy |
| Crysdot | CD31004893 | BV6 98+% | 50mg | $666 | 2021-12-16 | Buy |
Properties
Boiling point :1376.7±65.0 °C(Predicted)
Density :1.177±0.06 g/cm3(Predicted)
storage temp. :Keep in dark place,Inert atmosphere,Store in freezer, under -20°C
solubility :≥60.28 mg/mL in DMSO; insoluble in H2O; ≥12.6 mg/mL in EtOH with ultrasonic
form :solid
pka :12.89±0.20(Predicted)
color :White to off-white
Density :1.177±0.06 g/cm3(Predicted)
storage temp. :Keep in dark place,Inert atmosphere,Store in freezer, under -20°C
solubility :≥60.28 mg/mL in DMSO; insoluble in H2O; ≥12.6 mg/mL in EtOH with ultrasonic
form :solid
pka :12.89±0.20(Predicted)
color :White to off-white
Safety Information
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Description
BV6 is a bivalent Smac mimetic and an antagonist of the inhibitor of apoptosis (IAP) proteins that binds to IAP1 and XIAP (Kds = 0.46 and 1.3 nM, respectively). It induces autoubiquitination and proteasomal degradation of IAP1 and XIAP in MDA-MB-231 cells when used at a concentration of 5 μM. BV6 (4 μM) induces NF-κB activation and TNF-dependent apoptosis in A2058 and MDA-MB-231 cells. It enhances radiosensitization and increases apoptosis in HCC193 and H460 non-small cell lung cancer (NSCLC) cell lines. BV6 (1 μM) induces cell death in a panel of 40 primary, patient-derived B cell precursor acute lymphoblastic leukemia (BCP-ALL) samples in a TNF-dependent manner. In vivo, BV6 (10 mg/kg) increases survival and the time to relapse in a high-risk BCP-ALL patient-derived xenograft (PDX) mouse model.Related product price
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