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ChemicalBook >> CAS DataBase List >> (Z)-3-(3-(3,5-bis(trifluoroMethyl)phenyl)-1H-1,2,4-triazol-1-yl)-1-(3,3-

(Z)-3-(3-(3,5-bis(trifluoroMethyl)phenyl)-1H-1,2,4-triazol-1-yl)-1-(3,3-

(Z)-3-(3-(3,5-bis(trifluoroMethyl)phenyl)-1H-1,2,4-triazol-1-yl)-1-(3,3- price.
  • $36 - $1802
  • Product name: (Z)-3-(3-(3,5-bis(trifluoroMethyl)phenyl)-1H-1,2,4-triazol-1-yl)-1-(3,3-
  • CAS: 1421919-75-6
  • MF: C16H10F8N4O
  • MW: 426.26
  • EINECS:-0
  • MDL Number:MFCD27937049
  • Synonyms:(Z)-3-(3-(3,5-bis(trifluoroMethyl)phenyl)-1H-1,2,4-triazol-1-yl)-1-(3,3-;KPT-276;2-Propen-1-one, 3-[3-[3,5-bis(trifluoromethyl)phenyl]-1H-1,2,4-triazol-1-yl]-1-(3,3-difluoro-1-azetidinyl)-, (2Z)-;(KPT276)(Z)-3-(3-(3,5-bis(trifluoromethyl)phenyl)-1H-1,2,4-triazol-1-yl)-1-(3,3-difluoroazetidin-1-yl)prop-2-en-1-one;KPT276; KPT 276;(Z)-3-[3-[3,5-bis(trifluoromethyl)phenyl]-1,2,4-triazol-1-yl]-1-(3,3-difluoroazetidin-1-yl)prop-2-en-1-one;CS-1100;(Z)-3-(3-(3,5-bis(trifluoroMethyl)phenyl)-1H-1,2,4-triazol-1-yl)-1-(3,3- USP/EP/BP
17 prices
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  • Ambeed
  • ApexBio Technology
  • Biorbyt Ltd
  • Cayman Chemical
  • Crysdot
  • DC Chemicals
Package
  • 5mg
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  • ManufacturerAmbeed
  • Product numberA192347
  • Product description(Z)-3-(3-(3,5-Bis(trifluoromethyl)phenyl)-1H-1,2,4-triazol-1-yl)-1-(3,3-difluoroazetidin-1-yl)prop-2-en-1-one 98+%
  • Packaging5mg
  • Price$36
  • Updated2021-12-16
  • Buy
  • ManufacturerAmbeed
  • Product numberA192347
  • Product description(Z)-3-(3-(3,5-Bis(trifluoromethyl)phenyl)-1H-1,2,4-triazol-1-yl)-1-(3,3-difluoroazetidin-1-yl)prop-2-en-1-one 98+%
  • Packaging10mg
  • Price$61
  • Updated2021-12-16
  • Buy
  • ManufacturerAmbeed
  • Product numberA192347
  • Product description(Z)-3-(3-(3,5-Bis(trifluoromethyl)phenyl)-1H-1,2,4-triazol-1-yl)-1-(3,3-difluoroazetidin-1-yl)prop-2-en-1-one 98+%
  • Packaging50mg
  • Price$168
  • Updated2021-12-16
  • Buy
  • ManufacturerAmbeed
  • Product numberA192347
  • Product description(Z)-3-(3-(3,5-Bis(trifluoromethyl)phenyl)-1H-1,2,4-triazol-1-yl)-1-(3,3-difluoroazetidin-1-yl)prop-2-en-1-one 98+%
  • Packaging100mg
  • Price$286
  • Updated2021-12-16
  • Buy
  • ManufacturerAmbeed
  • Product numberA192347
  • Product description(Z)-3-(3-(3,5-Bis(trifluoromethyl)phenyl)-1H-1,2,4-triazol-1-yl)-1-(3,3-difluoroazetidin-1-yl)prop-2-en-1-one 98+%
  • Packaging250mg
  • Price$572
  • Updated2021-12-16
  • Buy
  • ManufacturerAmbeed
  • Product numberA192347
  • Product description(Z)-3-(3-(3,5-Bis(trifluoromethyl)phenyl)-1H-1,2,4-triazol-1-yl)-1-(3,3-difluoroazetidin-1-yl)prop-2-en-1-one 98+%
  • Packaging1g
  • Price$1745
  • Updated2021-12-16
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  • ManufacturerApexBio Technology
  • Product numberB1463
  • Product descriptionKPT-276
  • Packaging10mg
  • Price$68
  • Updated2021-12-16
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  • ManufacturerApexBio Technology
  • Product numberB1463
  • Product descriptionKPT-276
  • Packaging50mg
  • Price$189
  • Updated2021-12-16
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  • ManufacturerBiorbyt Ltd
  • Product numberorb180987
  • Product descriptionKPT-276 >98%
  • Packaging100mg
  • Price$606.9
  • Updated2021-12-16
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  • ManufacturerBiorbyt Ltd
  • Product numberorb180987
  • Product descriptionKPT-276 >98%
  • Packaging250mg
  • Price$912.9
  • Updated2021-12-16
  • Buy
  • ManufacturerBiorbyt Ltd
  • Product numberorb180987
  • Product descriptionKPT-276 >98%
  • Packaging1000mg
  • Price$1802
  • Updated2021-12-16
  • Buy
  • ManufacturerCayman Chemical
  • Product number29158
  • Product descriptionKPT-276
  • Packaging5mg
  • Price$68
  • Updated2024-03-01
  • Buy
  • ManufacturerCayman Chemical
  • Product number29158
  • Product descriptionKPT-276
  • Packaging10mg
  • Price$109
  • Updated2024-03-01
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  • ManufacturerCayman Chemical
  • Product number29158
  • Product descriptionKPT-276
  • Packaging25mg
  • Price$201
  • Updated2024-03-01
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  • ManufacturerCayman Chemical
  • Product number29158
  • Product descriptionKPT-276
  • Packaging50mg
  • Price$268
  • Updated2024-03-01
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  • ManufacturerCrysdot
  • Product numberCD31003540
  • Product descriptionKPT-276 98+%
  • Packaging50mg
  • Price$222
  • Updated2021-12-16
  • Buy
Manufacturer Product number Product description Packaging Price Updated Buy
Ambeed A192347 (Z)-3-(3-(3,5-Bis(trifluoromethyl)phenyl)-1H-1,2,4-triazol-1-yl)-1-(3,3-difluoroazetidin-1-yl)prop-2-en-1-one 98+% 5mg $36 2021-12-16 Buy
Ambeed A192347 (Z)-3-(3-(3,5-Bis(trifluoromethyl)phenyl)-1H-1,2,4-triazol-1-yl)-1-(3,3-difluoroazetidin-1-yl)prop-2-en-1-one 98+% 10mg $61 2021-12-16 Buy
Ambeed A192347 (Z)-3-(3-(3,5-Bis(trifluoromethyl)phenyl)-1H-1,2,4-triazol-1-yl)-1-(3,3-difluoroazetidin-1-yl)prop-2-en-1-one 98+% 50mg $168 2021-12-16 Buy
Ambeed A192347 (Z)-3-(3-(3,5-Bis(trifluoromethyl)phenyl)-1H-1,2,4-triazol-1-yl)-1-(3,3-difluoroazetidin-1-yl)prop-2-en-1-one 98+% 100mg $286 2021-12-16 Buy
Ambeed A192347 (Z)-3-(3-(3,5-Bis(trifluoromethyl)phenyl)-1H-1,2,4-triazol-1-yl)-1-(3,3-difluoroazetidin-1-yl)prop-2-en-1-one 98+% 250mg $572 2021-12-16 Buy
Ambeed A192347 (Z)-3-(3-(3,5-Bis(trifluoromethyl)phenyl)-1H-1,2,4-triazol-1-yl)-1-(3,3-difluoroazetidin-1-yl)prop-2-en-1-one 98+% 1g $1745 2021-12-16 Buy
ApexBio Technology B1463 KPT-276 10mg $68 2021-12-16 Buy
ApexBio Technology B1463 KPT-276 50mg $189 2021-12-16 Buy
Biorbyt Ltd orb180987 KPT-276 >98% 100mg $606.9 2021-12-16 Buy
Biorbyt Ltd orb180987 KPT-276 >98% 250mg $912.9 2021-12-16 Buy
Biorbyt Ltd orb180987 KPT-276 >98% 1000mg $1802 2021-12-16 Buy
Cayman Chemical 29158 KPT-276 5mg $68 2024-03-01 Buy
Cayman Chemical 29158 KPT-276 10mg $109 2024-03-01 Buy
Cayman Chemical 29158 KPT-276 25mg $201 2024-03-01 Buy
Cayman Chemical 29158 KPT-276 50mg $268 2024-03-01 Buy
Crysdot CD31003540 KPT-276 98+% 50mg $222 2021-12-16 Buy

Properties

Boiling point :477.2±55.0 °C(Predicted)
Density :1.56±0.1 g/cm3(Predicted)
storage temp. :Store at -20°C
solubility :insoluble in EtOH; insoluble in H2O; ≥19.85 mg/mL in DMSO
form :solid
pka :0.59±0.50(Predicted)
color :White to off-white

Safety Information

Symbol(GHS): GHS hazard pictograms
Signal word: Warning
Hazard statements:
Code Hazard statements Hazard class Category Signal word Pictogram P-Codes
H302 Harmful if swallowed Acute toxicity,oral Category 4 Warning GHS hazard pictograms P264, P270, P301+P312, P330, P501
H315 Causes skin irritation Skin corrosion/irritation Category 2 Warning GHS hazard pictograms P264, P280, P302+P352, P321,P332+P313, P362
H319 Causes serious eye irritation Serious eye damage/eye irritation Category 2A Warning GHS hazard pictograms P264, P280, P305+P351+P338,P337+P313P
H335 May cause respiratory irritation Specific target organ toxicity, single exposure;Respiratory tract irritation Category 3 Warning GHS hazard pictograms
Precautionary statements:
P261 Avoid breathing dust/fume/gas/mist/vapours/spray.
P305+P351+P338 IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

Description

KPT-276 is an orally bioavailable inhibitor of Exportin 1 (XPO1/CRM1) with anticancer activity. In vivo, KPT-276 (150 mg/kg) increases survival and reduces spleen weight and white blood cell count in an MV4-11 acute myeloid leukemia (AML) mouse xenograft model. It also reduces tumor volume and increases survival in a BT 145 glioblastoma mouse xenograft model when administered at a dose of 75 mg/kg.

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