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|---|---|
| Country: | China |
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Oxybutynin hydrochloride with good price
Release time: 2024-05-01
| Product Name:Oxybutynin hydrochloride | CAS No.:1508-65-2 |
| EC-No.:216-139-7 | Min. Order:1KG |
| Purity:99% | Supply Ability:50000KG/month |
| Release date:2024/3/13 |
| CAS: | 1508-65-2 |
| MF: | C22H32ClNO3 |
| MW: | 393.95 |
| EINECS: | 216-139-7 |
| Product Categories: | DITROPAN;Antibiotics;All Inhibitors;Inhibitors;Intermediates & Fine Chemicals;Pharmaceuticals |
| Mol File: | 1508-65-2.mol |
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| Oxybutynin hydrochloride Chemical Properties |
| Melting point | 122-124°C |
| storage temp. | room temp |
| solubility | H2O: soluble50mg/mL |
| form | powder |
| color | white |
| CAS DataBase Reference | 1508-65-2(CAS DataBase Reference) |
| Oxybutynin hydrochloride Usage And Synthesis |
| Chemical Properties | White to Off-White Solid |
| Originator | Ditropan, Marion , US ,1975 |
| Uses | An inhibitor of proliferation and supresses gene expression in bladder smooth muscle cells |
| Uses | anticholinergic |
| Uses | An antagonist of M1, M2, & M3 muscarinic acetylcholine receptors |
| Manufacturing Process | A mixture of 394.2 grams of methyl phenylcyclohexylglycolate and 293.1 grams of 4-diethylamino-2-butynyl acetate was dissolved with warming in 2.6 liters of n-heptane. The solution was heated with stirring to a temperature of 60° to 70°C and 8.0 grams of sodium methoxide were added. The temperature of the mixture was then raised until the solvent began to distill. Distillation was continued at a gradual rate and aliquots of the distillate were successively collected and analyzed for the presence of methyl acetate by measurement of the refractive index. The reaction was completed when methyl acetate no longer distilled, and the refractive index observed was that of pure heptane (nD26 = 1.3855). About 3? hours were required for the reaction to be completed. The reaction mixture was then allowed to cool to room temperature, washed with water, and extracted with four 165 ml portions of 2 N hydrochloric acid. The aqueous extracts were combined and stirred at room temperature to permit crystallization of the hydrochloride salt of the desired product. Crystallization was completed by cooling the slurry in an ice bath, and the product was collected by filtration, pressed dry, and recrystallized from 750 ml of water. Yield of pure crystalline material, 323 grams. |
| Brand name | Ditropan (ALZA). |
| Therapeutic Function | Spasmolytic |
| Biological Activity | oxybutynin is an anticholinergic medication used to relieve urinary and bladder difficulties. |
| Biochem/physiol Actions | Muscarinic acetylcholine receptor antagonist; inhibits proliferation of bladder smooth muscle cells, perhaps by downregulation of growth promoting genes. |
| Clinical Use | Urinary frequency, urgency and incontinence Neurogenic bladder instability and nocturnal enuresis |
| Safety Profile | Poison by ingestion, intravenous, and intraperitoneal routes. An experimental teratogen. Experimental reproductive effects. An eye irritant. Human systemic effects: coma, mydriasis, rate changes. An anticholinergic agent. When heated to decomposition it e |
| Drug interactions | Potentially hazardous interactions with other drugs Anti-arrhythmics: increased risk of antimuscarinic side effects with disopyramide. Other antimuscarinic agents: increased antimuscarinic effects. |
| Metabolism | Oxybutynin undergoes extensive first-pass metabolism, particularly by the cytochrome P450 isoenzyme CYP3A4. One of the metabolites, N-desethyloxybutynin is pharmacologically active. Oxybutynin and its metabolites are excreted in the urine and faeces. |
Packing &shipping&Payment
Shipping:by sea or by air
Payment:T/T,western union,moneygram
Packaging Details drum
Port:Tianjin
Lead Time :
| Quantity(Kilograms) | 1 - 10000 | >10000 |
| Est. Time(days) | 5 | To be negotiated |
Contact Information
Shanghai Ouda New New Material Science and Technology Center，located in Fengxian District, Shanghai. The company produces more than 1000 kinds of high-quality products I20 production lines to provide OEM services, as one of the most dynamic industry and trade integrated companies in the Chinese market.our advantage comes from our service, we can provide fast delivery. The average delivery time in peak season is less than 15 working days, and the average delivery time in off-season is less than 1 month. We have successfully transported many chemical raw materials to many countries in the world. Good feedback and repeat orders have supported the growth of our company.independent production lines, we have 20 pharmaceutical raw materials, organic solvents and other raw material production lines. In addition, we also have an API production workshop with independent research and development production lines, as well as an API research and development testing center. We can provide you with sample testing and accept small orders. Supply 99%+ quality chemical products. We believe only good quality can bring good cooperation, quality is our key spirit during our production, we are warmly welcome clients and partner from all over the world contact us for everlasting cooperation, Ouda will be your strong, sincere and reliable partner in China.
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