English name: Diflunisal

CAS number: 22494-42-4

Molecular formula: C13H8F2O3

Molecular weight: 250.2

EINECS number: 245-034-9

MDL No. : MFCD00057834

Stats

Melting point 207-209? C

Boiling point 386.9±42.0 °C(Predicted)

Density 1.3505 (estimate)

Storage conditions Keep in dark place,Sealed in dry,Room Temperature

Solubility Practically insoluble in water, soluble in ethanol (96 per cent). It dissolves in dilute solutions of alkali hydroxides.

Acidity coefficient (pKa)pKa 3.3 (H2O I=0.1) (Uncertain)

Morphological neat

Color White

Water solubility 6.186mg/L(24.99 ºC)

Safety information

hazard symbol (GHS)GHS hazard pictogramsGHS hazard pictograms

GHS07,GHS08

Warning word

Hazard Description H302-H315-H319-H335-H361

Precautions P201-P301+P312+P330-P302+P352-P305+P351+P338-P308+P313

Hazard category code 22-36/37/38-63

Safety Note 22-26-36

WGK Germany3

RTECS number DV2030000

Hazard NoteIrritant

Customs Code 2918290000

LD50 orally in female mice: 439 mg/kg (Stone)

    Diflunisal (MK-647) is a salicylate derivative with nonsteroidal anti-inflammatory and uric acid relieving properties, which can be used alone as an analgesic and in patients with rheumatoid arthritis. Diflunisal is an inhibitor of cyclooxygenase (COX).

       Diflunisal is more potent than aspirin but produces fewer side effects and has a biological half-life three to four times greater than that of aspirin. It is rapidly and completely absorbed on oral administration, with peak plasma levels being achieved within 2 to 3 hours of administration. It is highly bound (99%) to plasma proteins after absorption. Its elimination half-life is 8 to 12 hours, and it is excreted into urine primarily as glucuronide conjugates. The most frequently reported side effects include disturbances of the GI system (e.g., nausea, dyspepsia, and diarrhea), dermatological reactions, and CNS effects (e.g., dizziness and headache).

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