午夜插插,噜噜噜影院,啪啪伊人网,欧美熟夫,景甜吻戏视频,男人强操性感蕾丝美女视频在线网站,日本美女跳舞视频

ChemicalBook >> journal list >> ACS Applied Energy Materials >>article
ACS Applied Energy Materials

ACS Applied Energy Materials

IF: 5.4
Download PDF

Protective effects and mechanism of puerarin targeting PI3K/Akt signal pathway on neurological diseases.

Published:24 October 2022 DOI: 10.3389/fphar.2022.1022053 PMID: 36353499
Qian Wang, Zi-Nuo Shen, Shu-Jing Zhang, Yan Sun, Feng-Jie Zheng, Yu-Hang Li

Abstract

Neurological diseases impose a tremendous and increasing burden on global health, and there is currently no curative agent. Puerarin, a natural isoflavone extracted from the dried root of Pueraria montana var. Lobata (Willd.) Sanjappa and Predeep, is an active ingredient with anti-inflammatory, antioxidant, anti-apoptotic, and autophagy-regulating effects. It has great potential in the treatment of neurological and other diseases. Phosphatidylinositol 3-kinases/protein kinase B (PI3K/Akt) signal pathway is a crucial signal transduction mechanism that regulates biological processes such as cell regeneration, apoptosis, and cognitive memory in the central nervous system, and is closely related to the pathogenesis of nervous system diseases. Accumulating evidence suggests that the excellent neuroprotective effect of puerarin may be related to the regulation of the PI3K/Akt signal pathway. Here, we summarized the main biological functions and neuroprotective effects of puerarin via activating PI3K/Akt signal pathway in neurological diseases. This paper illustrates that puerarin, as a neuroprotective agent, can protect nerve cells and delay the progression of neurological diseases through the PI3K/Akt signal pathway.

Substances (3)

Related products
Procduct Name CAS Molecular Formula Supplier Price
Puerarin 3681-99-0 C21H20O9 608 suppliers $5.00-$2010.40
PI3K 20 suppliers Inquiry
AKT3 (AB-1) POLYCLONAL ANTIBODY 13 suppliers $282.00-$729.00