午夜插插,噜噜噜影院,啪啪伊人网,欧美熟夫,景甜吻戏视频,男人强操性感蕾丝美女视频在线网站,日本美女跳舞视频

ChemicalBook >> journal list >> European Journal of Medicinal Chemistry >>article
European Journal of Medicinal Chemistry

European Journal of Medicinal Chemistry

IF: 6
Download PDF

Design, synthesis, and antifungal activity of triazole and benzotriazole derivatives

Published:1 July 2009 DOI: 10.1016/j.ejmech.2008.07.012 PMID: 18760508
Zahra Rezaei , Soghra Khabnadideh , Keyvan Pakshir , Zahra Hossaini , Fatemeh Amiri , Elham Assadpour

Abstract

This study describes the design, synthesis and evaluation of a novel series of 1,2,4-triazole and benzotriazole derivatives as inhibitors of cytochrome P450 14α-demethylase (14DM). The chemical structures of the new compounds were confirmed by elemental and spectral (1H NMR, 13C NMR, Mass) analyses. Compounds were designed by a generating virtual library of compounds and docking them into the enzyme active site. Furthermore, they were found to have in vitro activity against Microsporum canis, Trichophyton mentagrophyte, Trichophyton rubrum, Epidermophyton floccosum, and Candida albicans comparable to fluconazole and clotrimazole.

Substances (10)

Related products
Procduct Name CAS Molecular Formula Supplier Price
Fluconazole 86386-73-4 C13H12F2N6O 1109 suppliers $5.00-$1504.50
1H-Benzotriazole 95-14-7 C6H5N3 1004 suppliers $6.00-$6515.49
1,2,4-Triazole 288-88-0 C2H3N3 919 suppliers $10.00-$2228.00
Clotrimazole 23593-75-1 C22H17ClN2 913 suppliers $10.00-$927.00
CANDIDA ALBICANS 33 suppliers Inquiry
Cytochrome P450 4V2 Antibody 18 suppliers Inquiry
Epidermophyton floccosum 8 suppliers Inquiry
Trichophyton rubrum 7 suppliers Inquiry
Microsporum canis 7 suppliers Inquiry
TRICHOPHYTON 1 suppliers Inquiry

Similar articles

IF:3.3

Antioxidant Activity of 1,2,4-Triazole and its Derivatives: A Mini-Review.

Mini reviews in medicinal chemistry Anna Pachuta-Stec,etc Published: 1 January 2022
IF:3.2

Capsaicin derivatives: Synthesis and biological activity

Chemical Biology & Drug Design Shun Liu, Xing Zheng,etc Published: 5 February 2024
IF:11.4

Toxicity of Benzotriazole and Benzotriazole Derivatives to Three Aquatic Species

Water Research David A Pillard , Jeffrey S Cornell ,etc Published: 1 February 2001