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International Journal of Biological Macromolecules

International Journal of Biological Macromolecules

IF: 7.7
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NIR-responsive injectable nanocomposite hydrogels with enhanced angiogenesis for promoting full-thickness wound healing

Published:11 December 2024 DOI: 10.1016/j.ijbiomac.2024.138688 PMID: 39672424
Yiyu Wang,?Chunqing Niu,?Guiting Yu,?Yuhong Lin,?Binbin Li,?Zheng Jin,?Xiaona Wu,?Jian Shi,?Chibo Liu,?Xinyu Wang,?Kai Zhao

Abstract

Angiogenesis plays a vital role in the treatment of full-thickness wounds. Deferoxamine (DFO) has been employed to promote neovascularization, however, smart drug delivery systems are needed to optimize its utilization. In this study, an injectable extracellular matrix (ECM)-mimicking hydrogel (HOG@P&D) was developed by leveraging the dynamic Schiff base and hydrogen bonds among a chitosan derivative (HACC), oxidized alginate (OSA), gelatin, and DFO-loaded polydopamine nanoparticles (P&D) for efficient wound healing. The incorporation of P&D enables HOG@P&D to respond to near-infrared (NIR) irradiation, converting laser energy into heat to trigger an on-demand, rapid release of DFO, thereby effectively enhancing angiogenesis. In vitro tube formation assays revealed that the number of meshes in the HOG@P&D group was fourfold higher than that of the control group. Additionally, HOG@P&D exhibited superior mechanical properties, tissue adhesion, and injectability, allowing it to cover wounds seamlessly. This hydrogel also demonstrated antibacterial and antioxidant properties, creating a conducive microenvironment for wound healing. In vivo studies further confirmed that HOG@P&D promoted angiogenesis and mitigated inflammation by upregulating angiogenic growth factor expression, thereby accelerating full-thickness wound healing. This nanocomposite hydrogel shows significant potential as a high-performance wound dressing.

Substances (5)

Materials
Procduct Name CAS Molecular Formula Supplier Price
Sodium alginate 9005-38-3 C5H7O4COONa 656 suppliers $14.00-$775.00
Gelatin 9000-70-8 C6H12O6 593 suppliers $22.70-$3510.00
Sodium periodate 7790-28-5 H2INaO4 459 suppliers $14.56-$2650.00
Lysozyme 12650-88-3 C125H196N40O36S2 433 suppliers $29.40-$2580.00
Collagenase 9001-12-1 C60H100N2 178 suppliers $59.90-$6110.00

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