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International Journal of Biological Macromolecules

International Journal of Biological Macromolecules

IF: 7.7
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Degradable chiral mesoporous silica nanoparticles and carboxymethyl chitosan/cystamine hydrogels for selective loading and controlled release of S-naproxen

Published:11 December 2024 DOI: 10.1016/j.ijbiomac.2024.138706 PMID: 39672415
Ze Xu,?Guodong Zhang,?Rongzhi Wang,?Guilin Zhang,?Guanyu Chen,?Huwei Bian,?Tao Jiang,?Yong Kong

Abstract

Degradable chiral mesoporous silica nanoparticles (DCMSN) are synthesized for selective loading and controlled release of S-naproxen (S-NPX). Chiral silane coupling agent (APTES-L) and degradable silane coupling agent (APTES-CN) are synthesized, respectively, which are used for the synthesis of DCMSN. APTES-L endows the DCMSN with chirality, while APTES-CN endows the DCMSN with degradability. Owing to the same rotatory directions of DCMSN and S-NPX, the DCMSN can be used for the selective loading of S-NPX, and the higher selectivity of DCMSN toward S-NPX is further confirmed by the thermodynamic computations. Further, the S-NPX loaded DCMSN (DCMSN-S-NPX) is encapsulated in the hydrogels cross-linked by carboxymethyl chitosan (CMCS) and cystamine (Cys). The TEM characterization reveals that the DCMSN has a regular and spherical shape, and the BET analysis demonstrates that the DCMSN is a typical mesoporous material. The thermogravimetry reveals that the contents of the silane coupling agents in the DCMSN are about 23.9?%. The results of UV and circular dichroism (CD) spectra indicate a higher selectivity of DCMSN toward S-NPX. The release of S-NPX from the hydrogels is controlled by pH and glutathione (GSH), and the release of S-NPX follows a zero-order equation. Cytotoxicity assay indicates that the drug-free hydrogels have excellent biocompatibility.

Substances (6)

Materials
Procduct Name CAS Molecular Formula Supplier Price
Glutathione 70-18-8 C10H17N3O6S 1133 suppliers $6.00-$3420.00
Hexadecyl trimethyl ammonium bromide 57-09-0 C19H42BrN 843 suppliers $6.00-$19422.00
Methanol 67-56-1 CH4O 836 suppliers $9.00-$7620.00
Ethanol 64-17-5 C2H6O 806 suppliers $10.00-$17310.00
Ammonia 7664-41-7 H3N 531 suppliers $15.00-$2840.72
Tetraethyl orthosilicate 78-10-4 C8H20O4Si 476 suppliers $12.00-$1350.00

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