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International Journal of Biological Macromolecules

International Journal of Biological Macromolecules

IF: 7.7
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Anti-inflammatory supramolecular hydrogel loaded chicoric acid based on graphene oxide modified hyaluronic acid and polyethylene glycol for rheumatoid arthritis?…

Published:9 December 2024 DOI: 10.1016/j.ijbiomac.2024.138610 PMID: 39662575
Chao Zhou,?Weina Hao,?Jiapei Yao,?Tianjun Zhu,?Mengdi Sun,?Yaojun Lu,?Liangliang Wang,?Xindie Zhou,?Jia Ling Celestine Loh

Abstract

Chicoric acid (CA) as one of Chinese medicines had anti-inflammatory, less gastrointestinal irritation, less drug-resistance and low cost properties compared with chemical synthesized drug and biologics for rheumatoid arthritis (RA) treatment. To make CA preciously and effectly RA therapy, we firstly developed a supramolecular hydrogel (GHCAP) comprising β-cyclodextrin and graphene oxide (GO) modified hyaluronic acid (CD-HA-GO) as the "host" polymer and adamantane-modified four-arm polyethylene glycol (PEG-AD) as the "guest" polymer, and then the CA was loaded into the supramolecular hydrogel (DGHCAP). The results showed that DGHCAP exhibited injectable, high modulus, high CA loading rate (43.38?%) and slow CA releasing ratio (releasing 80?% in 80?h) compared with those of the supramolecular hydrogel without GO (DHCAP). Moreover, the DGHCAP demonstrated excellent compatibility and effect anti-inflammatory (down regulated proinflammatory cytokines such as IL-1β, IL-6, TNF-α and iNOs) in both in vitro and in vivo assays. The supramolecular hydrogels loaded Chinese medicine could provide another method to treat RA in clinical.

Substances (11)

Materials
Procduct Name CAS Molecular Formula Supplier Price
Sodium bicarbonate 144-55-8 CHNaO3 1379 suppliers $10.00-$2070.00
Ammonium chloride 12125-02-9 ClH4N 1328 suppliers $10.00-$4400.00
4-Dimethylaminopyridine 1122-58-3 C7H10N2 1238 suppliers $6.00-$5370.00
Sodium hydroxide 1310-73-2 NaOH 1211 suppliers $14.00-$16472.00
Acetonitrile 75-05-8 C2H3N 1024 suppliers $61180.00
Tosyl chloride 98-59-9 C7H7ClO2S 665 suppliers $9.00-$925.00
Hyaluronic acid 9004-61-9 C14H22NNaO11 612 suppliers $60.00-$1174.00
Triton X-100 9002-93-1 (C2H4O)nC14H22O 532 suppliers $18.00-$610.00
Hexamethylenediamine 124-09-4 C6H16N2 393 suppliers $14.00-$626.08
Propidium iodide 25535-16-4 C27H34IN4+ 297 suppliers $29.00-$1780.00

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