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International Journal of Biological Macromolecules

International Journal of Biological Macromolecules

IF: 7.7
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Chitosan/polyvinyl alcohol-based magnetic hydrogel microspheres with controlled retention and regulated drug release for intravesical instillation

Published:8 December 2024 DOI: 10.1016/j.ijbiomac.2024.138412 PMID: 39657875
Peinan Yin,?Chengxiong Wei,?Anamaria Brozovic,?Chengwei Wu,?Wei Zhang

Abstract

As a clinically effective treatment for bladder cancer (BC), intravesical instillation still suffers from the debilitating efficacy triggered by frequent urination. Herein, the magnetic hydrogel microspheres (DOX-mMSs) with the incorporation of magnetic nanoparticles (MNPs) and doxorubicin (DOX) into polyvinyl alcohol (PVA)/chitosan (CS) are developed for intravesical instillation. The magnetic force initiated by the applied magnetic field (AMF) enables the long-term retention of DOX-mMSs in the bladder, and the convenient injection and excretion from the bladder can be accomplished in virtue of the micron size of the DOX-mMSs. Additionally, the pH-sensitive dissociation of CS and hydrazone bonds via which DOX is loaded into DOX-mMSs endows the possibility of controlled drug release by tuning the pH of the urine in the bladder. This dual control strategy is promising in intravesical treatment.

Substances (8)

Materials
Procduct Name CAS Molecular Formula Supplier Price
4-Dimethylaminopyridine 1122-58-3 C7H10N2 1239 suppliers $6.00-$5370.00
Sodium hydroxide 1310-73-2 NaOH 1212 suppliers $14.00-$16472.00
Pyridine 110-86-1 C5H5N 929 suppliers $9.00-$16860.00
Cyclohexane 110-82-7 C6H12 810 suppliers $10.00-$8580.00
Propidium iodide 25535-16-4 C27H34IN4+ 304 suppliers $29.00-$1780.00
D-Luciferin sodium salt 103404-75-7 C11H9N2NaO3S2 270 suppliers $37.00-$2470.00
PARAFFIN 8020-83-5 NULL 101 suppliers $36.80-$497.54
FETUIN 9014-81-7 NULL 67 suppliers $37.07-$4380.00

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