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International Journal of Biological Macromolecules

International Journal of Biological Macromolecules

IF: 7.7
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Immunological studies of Burkholderia multivorans O-antigen oligosaccharide-rsScpA193 conjugates as potential candidates for vaccine development

Published:7 December 2024 DOI: 10.1016/j.ijbiomac.2024.138570 PMID: 39653199
Guirong Wang,?Jielin Zhao,?Xin Zhang,?Shuying Li,?Chongzhen Sun,?Guofeng Gu

Abstract

The Burkholderia cepacia complex (Bcc) is a group of phenotypically similar but genotypically diverse Gram-negative bacteria that pose a significant threat to public health worldwide. Due to the absence of effective therapies, the development of an effective vaccine against Bcc infection is urgently needed. Lipopolysaccharide (LPS) O-antigens of B. multivorans (BM) are attractive immunogenic components and recognized as potential target antigens for vaccine development. In this study, we designed and prepared three BM oligosaccharide-based glycoconjugates rsScpA193-1-3 with rsScpA193 as a new carrier protein. We performed preliminarily immunological assessments to determine the immunogenicity of these glycoconjugates, alongside in vitro evaluations of their capacity to bind BM cells and trigger long-term immunological memory. Our findings revealed that the synthesized conjugate rsScpA193-1exhibited stronger immunogenicity and better recognition to trisaccharide 1 and nonasaccharide 3 than the other two glycoconjugates. Moreover, rsScpA193-1 could effectively bind to BM cells in vitro and successfully induce long-lasting immunological memory. Therefore, trisaccharide 1 was identified as an effective antigenic target, and the conjugate rsScpA193-1 may represent a promising candidate for BM vaccine development. Overall, our study presented the first exploitation of immunogenicity of BM oligosaccharide-protein conjugates and significantly paved the way for Bcc vaccine development.

Substances (2)

Materials
Procduct Name CAS Molecular Formula Supplier Price
N,N-Dimethylformamide 68-12-2 C3H7NO 1214 suppliers $11.20-$12200.00
Bovine albumin 9048-46-8 N/A 500 suppliers $15.00-$17060.00

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