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International Journal of Biological Macromolecules

International Journal of Biological Macromolecules

IF: 7.7
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Synergistic effect of inulin hydrogels on multi-strain probiotics for prevention of ionizing radiation-induced injury

Published:6 December 2024 DOI: 10.1016/j.ijbiomac.2024.138497 PMID: 39647719
Shumin Du,?Rui Sun,?Minting Wang,?Yubao Fang,?Yanping Wu,?Bochuan Yuan,?Yiguang Jin

Abstract

Prebiotics and probiotics are applied against multiple diseases including ionizing radiation-induced injury but their functions are not revealed enough. Here, we used a prebiotic, inulin hydrogels (IGs) to load multi-strain probiotics (MSPs) for protecting them from the gastrointestinal environment and improving their colonization in the gut; more importantly, they showed the synergistic effect against ionizing radiation-induced injury. Probiotics were embedded in a great number of channels of the IGs and used IGs as food. The MSP was composed of Clostridium butyricum (Cb), Bifidobacterium adolescentis (Ba), and Akkermansia muciniphila (Akk), which separately mainly produced butyl acid, acetic acid and lactic acid, and stimulated mucin proteins. Although the MSP showed higher effect against mouse radiation enteritis than the single probiotics and the similar effect to IGs, the IG/MSP-based synbiotic had the highest protection and improved many factors close to the normal levels, including animal physical activity, enteric barrier function, occludin and ZO-1 expressions, injury extension, the levels of pro-inflammatory factors (IL-6, TNF-α), gut microbiota, and short-chained fatty acids. Moreover, the synbiotic had strong protection against whole-body irradiation with high blood cell numbers, hemopoietic system recovery, and high levels of IL-3 and IL-10. IGs greatly synergized probiotics against ionizing radiation-induced injury.

Substances (4)

Materials
Procduct Name CAS Molecular Formula Supplier Price
L-Threonine 72-19-5 C4H9NO3 810 suppliers $4.77-$23730.00
N-Acetyl-D-Glucosamine 7512-17-6 C8H15NO6 724 suppliers $5.00-$1688.96
INULIN 9005-80-5 C18H32O16 369 suppliers $10.00-$5540.00
FLUORESCEIN ISOTHIOCYANATE-DEXTRAN 60842-46-8 76 suppliers $89.70-$1980.00

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