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Journal of Hazardous Materials

Journal of Hazardous Materials

IF: 12.19
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High Temperatures Promote Antibiotic Resistance Genes Conjugative Transfer under Residual Chlorine: Mechanisms and Risks

Published:26 November 2024 DOI: 10.1016/j.jhazmat.2024.136675
Wenya Zhao, Binghuang Zhang, Chengsong Ye

Abstract

The impact of residual chlorine on the dissemination of antibiotic resistance during the distribution and storage of water has become a critical concern. However, the influence of rising temperatures attributed to global warming on this process remains ambiguous, warranting further investigation. This study investigated the effects of different temperatures (17, 27, 37, and 42°C) on the conjugative transfer of antibiotic resistance genes (ARGs) under residual chlorine (0, 0.1, 0.3, and 0.5?mg/L). The results indicated that high temperatures significantly increased the conjugative transfer frequency of ARGs in intra-species under residual chlorine. Compared to 17°C, the transfer frequencies at 27°C, 37°C, and 42°C increased by 1.07–2.43, 1.20–4.80, and 1.24–2.82 times, respectively. The promoting effect of high temperatures was mainly due to the generation of reactive oxygen species, the triggered SOS response, and the formation of pilus channels. Transcriptomic analysis demonstrated that higher temperature stimulates the electron transport chain, thereby enhancing ATP production and facilitating the processes of conjugative, as confirmed by inhibitor validation. Additionally, rising temperatures similarly promoted the frequency of conjugative transfer in inter-species and communities under residual chlorine. These further highlighted the risk of antibiotic resistance spread in extreme and prolonged high-temperature events. The increased risk of antibiotic resistance in the process of drinking water transmission under the background of climate warming is emphasized.

Substances (5)

Materials
Procduct Name CAS Molecular Formula Supplier Price
Chloramphenicol 56-75-7 C11H12Cl2N2O5 886 suppliers $24.10-$2397.16
Ampicillin 69-53-4 C16H19N3O4S 534 suppliers $13.00-$499.00
Tetracycline 60-54-8 C22H24N2O8 355 suppliers $14.00-$389.00
KANAMYCIN 59-01-8 C18H36N4O11 193 suppliers $25.00-$1372.96
Streptomycin 57-92-1 C21H39N7O12 144 suppliers Inquiry