Pyrroloquinoline quinone disodium salt is the disodium salt form of Pyrroloquinoline quinone (PQQ) and has similar effects and benefits to PQQ. The estimated daily dietary intake of Pyrroloquinoline quinone disodium salt is 100 – 400 micrograms, but this is difficult to achieve. The baseline intake of PQQ is considered to be 20 mg/day. This is considered safe for most adults, except for pregnant or breastfeeding women. In addition, if you are taking other supplements or medications, please consult your doctor before deciding whether to take PQQ.

There is no specific time to take PQQ. However, because of its potential to be energizing, most people think that the best time is usually in the morning with breakfast or before lunch. This time allows the body to absorb and utilize the supplement throughout the day.

Studies on the genotoxic potential of Pyrroloquinoline quinone disodium salt also showed that PQQ disodium salt is safe. Results of the bacterial mutation assay (Ames test) were negative. In an in vitro chromosome aberration assay performed in human peripheral blood lymphocytes, no genotoxic activity of PQQ was observed. In an in vivo micronucleus assay in mice, PQQ at doses up to 2000 mg/kg body weight showed no in vivo genotoxic effects in bone marrow erythrocytes. Weakly positive results were obtained in 2 independent in vitro chromosome aberration assays performed in Chinese hamster lung (CHL) fibroblasts. Overall, PQQ disodium has no genotoxic activity in vivo.

References:

[1] KAZUTO IKEMOTO; Mitsugu A; Nur Syafiqah Mohamad Ishak. The effects of pyrroloquinoline quinone disodium salt on brain function and physiological processes.[J]. JOURNAL OF MEDICAL INVESTIGATION, 2024, 71 1.2: 23-28. DOI:10.2152/jmi.71.23.

[2] MASAHIKO NAKANO . Genotoxicity of pyrroloquinoline quinone (PQQ) disodium salt (BioPQQ?)[J]. Regulatory Toxicology and Pharmacology, 2013, 67 2: Pages 189-197. DOI:10.1016/j.yrtph.2013.07.007.