Overview of Polyhexamethylene Guanidine Hydrochloride

Polyhexamethyleneguanidine hydrochloride is a compound known for its antimicrobial properties. It is a polymer that consists of repeating units of hexamethyleneguanidine and hydrochloride ions. Polyhexamethyleneguanidine hydrochloride is used as a disinfectant and preservative in various industries, including healthcare, water treatment, and personal care. It exhibits broad-spectrum antimicrobial activity against bacteria, viruses, and fungi. The compound is effective in controlling the growth of microorganisms and preventing their spread. Polyhexamethyleneguanidine hydrochloride is also used in wound care products, surface disinfectants, and as a biocide in cooling towers and industrial water systems. It is a colorless to pale yellow liquid or solid, depending on the form. The compound is soluble in water and has a pH range of 3.5 to 5.5. Polyhexamethyleneguanidine hydrochloride is considered safe for use when used according to recommended guidelines and concentrations. However, it is important to follow proper handling and storage procedures to ensure its effectiveness and minimize potential risks.

Figure 1 Characteristics of Polyhexamethyleneguanidine hydrochloride

Application of Polyhexamethylene Guanidine Hydrochloride

Skin wound disinfectant

Polyhexamethyleneguanidine hydrochloride is colorless, non-corrosive, and has long-lasting effectiveness, so it can be conveniently used for cleaning and disinfection of skin, wounds, obstetrics and gynecology, and urology. Especially for some medical supplies that cannot be sterilized by high temperature, you only need to soak or spray with a solution of 1‰ concentration to achieve a satisfactory sterilization effect in a short time. This product can also be used to disinfect the air, walls, and floors of wards.

Public place sterilization and purification agent

In public places, a large number of bacterial and viral infectious diseases seriously endanger human life safety. Sterilization and disinfection have become indispensable to protect people's lives. Link. This product has the characteristics of a broad sterilization spectrum, non-toxic, colorless, odorless, and non-corrosive. It is very suitable for sterilizing cars, trains, airplanes, ships, shopping malls, hospitals, cinemas, hotels, restaurants, and other public places. disinfect.

Athlete's foot and skin diseases

Polyhexamethyleneguanidine hydrochloride has a strong fungicidal effect and long-lasting effect, so it can be conveniently used for blisters, erosions, and scaly corners caused by fungal infections. Athlete's foot and tinea pedis, such as chemical and peeling types; various fungal skin diseases such as tinea cruris, tinea capitis, tinea corporis, and tinea manuum. It also plays the role of relieving itching, removing putrefaction, promoting muscle growth, and restoring normal skin functions.

Detergent supplies

Detergent supplies with disinfection functions on the market generally add chlorine preparations as disinfection ingredients, which are corrosive to fabrics, fade, have a short sterilization validity period, and can only Used for defects such as white fabrics. This product has the advantages of being soluble in water, non-toxic, colorless, odorless, non-corrosive, non-fading, non-irritating to skin and mucous membranes, and has a long validity period. It can develop high-tech, environmentally friendly disinfection and sterilization for washing fabrics of any color—products such as washing powder, detergent, dry cleaning agents, etc.

Sterilization and disinfection have become an indispensable and important part of people's daily lives. The advent of this product will have a broad market prospect. This product can not only kill various infectious bacteria on clothes and prevent the spread of sexually transmitted diseases but also has significant antibacterial and mildew-proof effects on washed clothes. It is especially important for children whose immune systems have not yet developed fully, and play a health protection role.

Toxicity of Polyhexamethylene Guanidine Hydrochloride

Preliminary results indicate that Polyhexamethylene guanidine hydrochloride and its derivatives mainly rely on disrupting cell membranes by inhibiting the activity of cell dehydrogenases. When Polyhexamethylene guanidine hydrochloride is nebulized and inhaled, it can harm the lungs, causing cell death in the walls of bronchioles and extensive damage to alveoli, as well as bronchiolitis obliterans, a typically fatal irreversible obstructive lung disease in which the bronchioles are compressed and narrowed due to fibrosis (scar tissue) and/or inflammation.

Reference

[1] Wei D, Ma Q, Guan Y, et al. Structural characterization and antibacterial activity of oligoguanidine (polyhexamethylene guanidine hydrochloride)[J]. Materials Science and Engineering: C, 2009, 29(6): 1776-1780.

[2] Choi H, Kim K J, Lee D G. Antifungal activity of the cationic antimicrobial polymer-poly hexamethylene guanidine hydrochloride and its mode of action[J]. Fungal Biology, 2017, 121(1): 53-60.