Methyl acetoacetate:Lewis structure,Scent,Synthesis and Hazard
Apr 15,2025
Methyl acetoacetate is a colourless liquid; there is special smell, soluble in water. It is an extremely weak basic(essentially neutral) compound (based on its pKa).
Lewis structure
Scent
Methyl acetoacetate acid has a scent of citrus, fresh, and fruity tasting.
Synthesis
The synthesis method of the methyl acetoacetate, in turn include the following steps: (1) joins reaction kettle of the esterification after methyl alcohol and catalyzer fully being dissolved, heat up, drip ketene dimer, (2) dropwise, insulation, cooling, generates methyl acetoacetate crude product, (3) gained crude product is through rectifying, obtain methyl acetoacetate finished product, it is characterized in that, the catalyzer in described step (1) is amine type ionic-liquid catalyst;
Described amine type ionic-liquid catalyst be selected from nitric acid n-Butyl Amine 99, acetic acid n-Butyl Amine 99, nitric acid ethamine, acetate triethylamine, nitric acid propylamine, acetic acid propylamine one or more.
Uses
Methyl acetoacetate' uses is that:
1.sterilant dislikes mould spirit, dimethirimol, the phonetic phenol of second for medicine industry;
2.methyl acetoacetate, sterilant diazinon, Coumaphos, pirimioxyphos, herbicide imazethapyr, the intermediate of rodenticide coumatetralyl, warfarin etc;
3.as the solvent of ether of cellulose and the composition of celluosic resin mixed solvent, also in the organic syntheses such as agricultural chemicals, medicine, dyestuff, macromolecule stabilizer.
Hazard
Methyl acetoacetate is minimum hazard. If spilled on clothing and allowed to remain, may cause smarting and reddening of skin.
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