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Flurbiprofen: Synthesis and Application

Mar 16，2024

Synthesis of Flurbiprofen

Ethyl 2-fluoro-4-biphenylacetate, prepared from 4-acetyl-2-fluorobiphenyl via the Willgerodt reaction and subsequent esterification, is treated first with diethyl carbonate and sodium ethoxide, then with dimethyl sulfate to give diethyl 2-(2-fluoro-4-biphenylyl)-2-methyl malonate. Saponification followed by acidification affords the malonic acid, which is decarboxylated at 180 – 200 ?C to yield flurbiprofen.

Flurbiprofen

Application of Flurbiprofen

Flurbiprofen has been used at 150 ~ 300 mg/d in the treatment of rheumatoid arthritis, osteoarthritis, and ankylosing spondylitis. Gastrointestinal disturbances, particularly dyspepsia, are the principal adverse effects.

Trade names

Ansaid (Pharmacia & Upjohn, CIS; Upjohn, Canada, Czech Republic, Poland, USA), Cebutid (Knoll, France), Froben (Kanoldt, Germany; Ebewe, Austria; Boots, Spain, The Netherlands, Portugal), Tulip (Upjohn, Spain).

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Flurbiprofen

5104-49-4

Flurbiprofen manufacturers

  • Flurbiprofen
  • 5104-49-4 Flurbiprofen
  • $0.00 / 1Kg/Bag
  • 2025-04-30
  • CAS:5104-49-4
  • Min. Order: 1KG
  • Purity: 99%-100.5%; BP
  • Supply Ability: 500 KGS
  • Flurbiprofen
  • 5104-49-4 Flurbiprofen
  • $40.00 / 1box
  • 2025-04-29
  • CAS:5104-49-4
  • Min. Order: 1box
  • Purity: 99.9+
  • Supply Ability: 2000box
  • Flurbiprofen
  • 5104-49-4 Flurbiprofen
  • $40.00 / 1box
  • 2025-04-29
  • CAS:5104-49-4
  • Min. Order: 1box
  • Purity: 99.9+
  • Supply Ability: 2000box