產(chǎn)品英文名稱: Recombinant Human B-Cell Leukemia/Lymphoma 2 XL
英文簡稱:Bcl-XL
中文名稱:重組人B細(xì)胞淋巴瘤因子2 XL
背景資料:Bcl-XL is a transmembrane protein located in the mitochondrial membranes of cells that are long-lived and postmitotic, such as adult brain cells. It plays arole in the signal transduction pathway of the FAS-Ligand. Bcl-XL is an anti-apoptotic protein which is a member of the Bcl-2 family which are able to form heterodimers, and this is an significant event in the regulation of apoptosis. BCL-XL is involved in the survival of cancer cells.Bcl-xL is the leading monitor of apoptosis/active cell suicide. Bcl-xL has cell death repressor activity and therefore acts as a survival protein.
產(chǎn)品描述:Bcl-XL Human Recombinant produced in E.Coli is a single, non-glycosylated polypeptide chain containing amino acids 1-210.The Bcl-XL is purified by proprietary chromatographic techniques.
來源宿主:大腸桿菌中重組表達(dá)
序列:溶解建議:Sterile Filtered White lyophilized (freeze-dried) powder. The protein contains 10mM Tris-HCL pH-8, 1mM EDTA and 250mM NaCl. Suspend BclXL in 100?l of 0.5M Acetic acid, over night at 4°C.Dilute 10 fold into selected buffer system.Bcl-XL has tendency to form intramolecular disulfide bond, 5mM DTT is recommended in assay buffer. When running SDS-PAGE gel, 10mM DTT is recommended.
保存建議:Lyophilized Bcl-XL although stable at room temperature for 3 weeks, should be stored desiccated below -18℃. Upon reconstitution Bcl-XL should be stored at 4℃ between 2-7 days and for future use below-18℃.For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Please prevent freeze-thaw cycles.
其他簡介:? ProSpec是一家全球著名細(xì)胞因子蛋白及相關(guān)抗體生產(chǎn)和研發(fā)品牌。ProSpec的生產(chǎn)和研發(fā)工廠位于以色列,專注于蛋白(重組及合成)生產(chǎn)研發(fā),其獨(dú)有的細(xì)菌和哺乳動物表達(dá)和蛋白折疊技術(shù)使其能在17年內(nèi)成長為國際一流的科研級蛋白供應(yīng)商。目前ProSpec可以提供細(xì)胞因子,生長因子,激素,信號蛋白,病毒抗原等近800種重組蛋白和100多種抗體,是世界上提供蛋白品種最多的公司之一,領(lǐng)先的生產(chǎn)工藝和規(guī)模使其可以提供毫克到克級蛋白,價格優(yōu)于同類公司。絕大部分產(chǎn)品是天然成熟型蛋白,而不含有標(biāo)簽蛋白??紤]到大部分研究者希望能更靈活地配制蛋白溶液,ProSpec-Tany絕大部分產(chǎn)品沒有添加保護(hù)劑或鹽,這就對工藝提出了更高的要求。同時,ProSpec-Tany絕大部分產(chǎn)品為凍干粉,因此易于運(yùn)輸和保存。
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溫馨提示:不可用于臨床治療。