Wuhan Eighteen International Trade Co.,ltd was founded in 2016
located in Hubei province is a well-known trading company in
China. We collaborate with international producers which the
plant was equipped with latest and most advanced GMP
facilities to supply highest quality and to be a prominent exporter
and distributor of different types of ingredients which covering
all applications for Pharmaceutical, Food & Nutraceutical, Feed,
Cosmetic and Oil & Plant extracts throughout the Asia Pacific
region.
We provide customers with value-added products and solutions
such as developing of new formulation and powder blending to
cater for ever increasing and sophisticated needs of its
customers. We also supply semi-finished products & finished
products for custom branding and contract manufacturing
services.
Name: Allopurinol
Synonyms: 4-Hydroxypyrazolo[3,4-d]pyrimidine; 1H-Pyrazolo[3,4-d]pyrimidin-4-ol; HPP
Molecular Formula: C5H4N4O
Molecular Weight: 136.11
CAS NO: 315-30-0
EINECS: 206-250-9
Quality standard: USP33, EP6.8 Pass GMP
Melting point: 350 ºC
Water solubility: 0.35 g/L (25 ºC)
Physical and Chemical Properties: White or white powder, insoluble in water.
function:
Allopurinol CAS 315-30-0 can cause severe pancytopenia if given with full-dose mercaptopurine or its pro-drug azathioprine, due to the inhibition of xanthine oxidase that metabolizes mercaptopurine. For this reason, allopurinol CAS 315-30-0 has been strongly contraindicated during thiopurine therapy in the past. However, in recent years the use of allopurinol cas 315-30-0 in combination with azathioprine or mercaptopurine has been revived. First, allopurinol cas 315-30-0 was shown that an azathioprine/allopurinol combination significantly improved renal transplant graft survival. More recently, allopurinol cas 315-30-0 was discovered that this co-therapy greatly improves the outcome for patients that do not respond to thiopurine monotherapy when treating inflammatory bowel disease (IBD), specifically Crohn's disease.
1. Reperfusion injury
Other established indications for allopurinol therapy include ischemic reperfusion injury, kidney stones with a uric acid component (uric acid nephrolithiasis), and protozoal infections (Leishmaniasis).
2. Renal disease, Heart failure and Angina
Allopurinol can be used in patients with poor kidney function, but it may also help them. A study of allopurinol use in patients with chronic kidney disease suggested that "Allopurinol decreases C-reactive protein and slows down the progression of renal disease in patients with chronic kidney disease. In addition, allopurinol reduces cardiovascular and hospitalization risk in these subjects."
3. Epilepsy
Allopurinol CAS 315-30-0 is used as an add-on drug for refractory epilepsy, because it is an adenosine agonist, which inhibits glutamine release from excitatory neurons, but does not change the plasma concentration of other epilepsy drugs.
4. Blood pressure
Allopurinol CAS 315-30-0 can decrease blood pressure reducing hypertension.
Specification:
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