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細(xì)胞穿透肽PF6,PepFect 6
  • 細(xì)胞穿透肽PF6,PepFect 6

細(xì)胞穿透肽PF6

價格 1500
包裝 1MG
最小起訂量 1MG
發(fā)貨地 上海
更新日期 2019-06-04

產(chǎn)品詳情

中文名稱:細(xì)胞穿透肽PF6英文名稱:PepFect 6
純度規(guī)格: 85%產(chǎn)品類別: 活性肽
2019-06-04 細(xì)胞穿透肽PF6 PepFect 6 1MG/1500RMB 1500 85% 活性肽

Product name: PepFect 6

Catalog#: 1101011

Synonyms: PepFect-6, PF6, Stearyl-AGYLLGK*(εNH)INLKALAALAKKIL

Sequence: Stearyl-Ala-Gly-Tyr-Leu-Leu-Gly-Lys(QN4-MAP4)-Ile-Asn-Leu-Lys-Ala-Leu-Ala-Ala-Leu-Ala-Lys-Lys-Ile-Leu-NH2

Modifications: N-terminal Stearic Acid, C-terminal amide,

M.W: 4410.29

M.F.: C216H339F12N49O35

Purity: 85%

Counter ion: Trifluoacetate

Format: Lyophilized powder

Description: PepFect 6 (PF6), a novel CPP, comprising the previously reported stearyl-TP10 peptide, having pH titratable trifluoromethylquinoline moieties covalently incorporated to facilitate endosomal release. Stable PF6/siRNA nanoparticles enter entire cell populations and rapidly promote endosomal escape, resulting in robust RNAi responses in various cell types (including primary cells), with minimal associated transcriptomic or proteomic changes. Furthermore, PF6-mediated delivery is independent of cell confluence and, in most cases, not significantly hampered by serum proteins. Finally, these nanoparticles promote strong RNAi responses in different organs following systemic delivery in mice without any associated toxicity. Strikingly, similar knockdown in liver is achieved by PF6/siRNA nanoparticles and siRNA injected by hydrodynamic infusion, a golden standard technique for liver transfection. These results imply that the peptide, in addition to having utility for RNAi screens in vitro, displays therapeutic potential. The structure of PF6 is based on that for PF3 with the addition of covalently linked, titratable, trifluoromethylquinoline moieties. Trifluoromethylquinoline is an analog of chloroquine which is the lysosomotropic agent, inhibiting endosome acidification, leading to endosomal swelling and rupture. As it has been shown, co-incubation of TP10‐oligonucleotide complex with quinacrine greatly increased the efficiency of the splice correction by cargo oligonucleotide. Therefore, including the analog of quinacrine into the PF3 structure thus obtaining PF6 seemed a logical development. As a result, in comparison to TP10 and PF3, PF6 is much more potent delivery vector for siRNA in vitro and in vivo, presumably by trifluoromethylquinoline promoted escape from endosomes by osmotic swelling and thus decreasing endosomal breakdown of CPPs and cargo by delaying endosome acidification.

關(guān)鍵字: PepFect 6, PF6

公司簡介

燊肽科技致力于為國內(nèi)醫(yī)藥研發(fā)機(jī)構(gòu)和科研院校提供多肽和氨基酸衍生物相關(guān)生化試劑, 以及定制合成技術(shù)服務(wù). 我們的產(chǎn)品線包含各種高端進(jìn)口品牌,以及價格適中的國內(nèi)自主品牌. 我們保證多肽實驗活性和質(zhì)量, 提供24小時技術(shù)支持.A full-service company dedicated to provide qualified peptide related chemicals, proteins and enabling technologies for scientific research. We are serving over 100 customers over North America, Europe , Japan, Korea, Australia Russia, and Latin America. The comprehensive services which assist you on peptides, intermediates manufacturing from the very beginning of pharma research to large
成立日期 2015-04-10 (10年) 注冊資本 100萬
員工人數(shù) 1-10人 年營業(yè)額 ¥ 300萬-500萬
主營行業(yè) 中間體,化學(xué)試劑,技術(shù)服務(wù) 經(jīng)營模式 貿(mào)易,工廠,試劑,定制,服務(wù)
  • 燊肽科技(上海)有限公司
非會員
  • 公司成立:10年
  • 注冊資本:100萬
  • 企業(yè)類型:貿(mào)易
  • 主營產(chǎn)品:氨基酸衍生物, 多肽及其鏈接劑, PEG以及多肽化學(xué)合成服務(wù)
  • 公司地址:奉賢區(qū)望園南路1288弄卓越世紀(jì)中心3號樓507房間
詢盤

細(xì)胞穿透肽PF6相關(guān)廠家報價

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2025-01-28
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2025-01-25
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