Human LRRC4 Protein, His Tag
分子別名(Synonym)
LRRC4,NGL-2,BAG,NAG14
表達區(qū)間及表達系統(tǒng)(Source)
Human LRRC4, His Tag (LR4-H5221) is expressed from human 293 cells (HEK293). It contains AA Ala 39 - Lys 527 (Accession # AAI11562.1).
Predicted N-terminus: Ala 39
蛋白結(jié)構(gòu)(Molecular Characterization)
This protein carries a polyhistidine tag at the C-terminus.
The protein has a calculated MW of 55.8 kDa. The protein migrates as 90-110 kDa when calibrated against Star Ribbon Pre-stained Protein Marker under reducing (R) condition (SDS-PAGE) due to glycosylation.
內(nèi)毒素(Endotoxin)
Less than 1.0 EU per μg by the LAL method.
純度(Purity)
>90% as determined by SDS-PAGE.
制劑(Formulation)
Lyophilized from 0.22 μm filtered solution in PBS, pH7.4 with trehalose as protectant.
Contact us for customized product form or formulation.
重構(gòu)方法(Reconstitution)
Please see Certificate of Analysis for specific instructions.
For best performance, we strongly recommend you to follow the reconstitution protocol provided in the CoA.
存儲(Storage)
For long term storage, the product should be stored at lyophilized state at -20°C or lower.
Please avoid repeated freeze-thaw cycles.
This product is stable after storage at:
-20°C to -70°C for 12 months in lyophilized state;
-70°C for 3 months under sterile conditions after reconstitution.
背景(Background)
LRRC4(富含亮氨酸重復(fù)序列/LRR的糖蛋白4)、LRRC4B和LRRC4C是誘導(dǎo)興奮性突觸形成的LRR蛋白家族的突觸后粘附分子。LRRC4也被稱為腦腫瘤相關(guān)蛋白BAG、Netrin-G2配體(NGL-2)、鼻咽癌相關(guān)基因14蛋白(G14),其含有1個Ig樣(免疫球蛋白樣)結(jié)構(gòu)域和9個LRR(富含亮氨酸)重復(fù)序列、1個LRRCT結(jié)構(gòu)域、1個LRONT結(jié)構(gòu)域。LRRC4/NGL-2在腦中特異性表達。LRRC4/NGL-2通過募集突觸前和突觸后蛋白來調(diào)節(jié)興奮性突觸的形成。LRRC4/NGL-2組織樹突的膜/通路特異性分化。LRRC4/NGL-2在聽覺突觸反應(yīng)中起著重要作用,并參與了膠質(zhì)瘤的抑制。
關(guān)鍵字: LRRC4;LRRC4蛋白;LRRC4重組蛋白;ACRO;百普賽斯;
百普賽斯集團ACROBiosystems Group(股票代碼:301080)是成立于2010年的跨國生物科技公司,是為全球生物醫(yī)藥、健康產(chǎn)業(yè)領(lǐng)域提供關(guān)鍵生物試劑產(chǎn)品及解決方案的行業(yè)平臺型基石企業(yè)。2021年在創(chuàng)業(yè)板上市。百普賽斯集團業(yè)務(wù)遍布全球,橫跨亞洲、北美洲、歐洲,在中國、美國、瑞士等12個城市設(shè)有辦公室、研發(fā)中心及生產(chǎn)基地。目前累計服務(wù)客戶超6000家,與全球Top 20醫(yī)藥企業(yè)均建立了長期、穩(wěn)定的合作伙伴關(guān)系。集團旗下?lián)碛衅放艫CROBiosystems百普賽斯、bioSeedin柏思薈、Condense Capital墾拓資本和ACRODiagnostics百斯醫(yī)學(xué)等。