PE-Labeled Mouse SIRP alpha Protein, His Tag (Site-specific conjugation)
分子別名（Synonym）
SHPS1,SIRPA,CD172A,BIT,MFR,MYD1,P84,PTPNS1
表達區(qū)間及表達系統(tǒng)（Source）
PE-Labeled Mouse SIRP alpha, His Tag (SIA-MP2H6) is produced via site-specific conjugation of PE to Mouse SIRP alpha, His Tag under optimal conditions with a proprietary technology. Mouse SIRP alpha, His Tag is expressed from human 293 cells (HEK293). It contains AA Lys 32 - Asn 373 (Accession # P97797-1).
Predicted N-terminus: Lys 32
蛋白結構（Molecular Characterization）
This protein carries a polyhistidine tag at the C-terminus.
The protein has a calculated MW of 41.5 kDa.
應用說明（Application）
Please note that this product is NOT compatible to streptavidin detection system.
Conjugate
PE
Excitation Wavelength: 488 nm / 561 nm
Emission Wavelength: 575 nm
制劑（Formulation）
Lyophilized from 0.22 μm filtered solution in PBS, 0.5% BSA, pH7.4. Normally trehalose is added as protectant before lyophilization.
Contact us for customized product form or formulation.
重構方法（Reconstitution）
Please see Certificate of Analysis for specific instructions.
For best performance, we strongly recommend you to follow the reconstitution protocol provided in the CoA.
存儲（Storage）
For long term storage, the product should be stored at lyophilized state at -20°C or lower.
Please protect from light and avoid repeated freeze-thaw cycles.
This product is stable after storage at:
-20°C to -70°C for 12 months in lyophilized state;
-70°C for 3 months under sterile conditions after reconstitution.
背景（Background）
酪氨酸蛋白磷酸酶非受體型底物1（SHPS1）也稱為CD172抗原樣家族成員A（CD172a）、巨噬細胞融合受體、MyD-1抗原、信號調節(jié)蛋白α（SIRPA或SIRPα）或p84，是SIRP家族的成員，也屬于免疫球蛋白超家族。SIRP-alpha在大腦中普遍存在并高度表達。SIRPA/CD172a是CD47的免疫球蛋白樣細胞表面受體，作為對接蛋白，誘導PTPN6、PTPN11和其他結合伴侶從細胞質轉移到質膜。SIRPA/SHPS-1支持小腦神經(jīng)元的粘附、神經(jīng)突起的生長和神經(jīng)膠質細胞的附著，可能在突觸發(fā)生過程中的細胞內信號傳導和突觸功能中發(fā)揮關鍵作用。SIRPA/MyD1參與細胞粘附、生長因子或胰島素誘導的受體酪氨酸激酶偶聯(lián)細胞反應的負調控，并介導吞噬作用、肥大細胞活化和樹突狀細胞活化的負調控。CD47結合阻止未成熟樹突細胞的成熟，并抑制成熟樹突細胞產生細胞因子。
關鍵字： SIRP alpha;SIRP alpha蛋白;SIRP alpha重組蛋白;ACRO;百普賽斯;
百普賽斯集團ACROBiosystems Group（股票代碼：301080）是成立于2010年的跨國生物科技公司，是為全球生物醫(yī)藥、健康產業(yè)領域提供關鍵生物試劑產品及解決方案的行業(yè)平臺型基石企業(yè)。2021年在創(chuàng)業(yè)板上市。百普賽斯集團業(yè)務遍布全球，橫跨亞洲、北美洲、歐洲，在中國、美國、瑞士等12個城市設有辦公室、研發(fā)中心及生產基地。目前累計服務客戶超6000家，與全球Top 20醫(yī)藥企業(yè)均建立了長期、穩(wěn)定的合作伙伴關系。集團旗下?lián)碛衅放艫CROBiosystems百普賽斯、bioSeedin柏思薈、Condense Capital墾拓資本和ACRODiagnostics百斯醫(yī)學等。