Rabies virus (strain CVS-11) Glycoprotein G, His Tag (MALS verified)
分子別名(Synonym)
Glycoprotein G
表達(dá)區(qū)間及表達(dá)系統(tǒng)(Source)
Rabies virus (strain CVS-11) Glycoprotein G, His Tag (RAG-V55H5) is expressed from Baculovirus-Insect cells.
Predicted N-terminus: Lys 20
蛋白結(jié)構(gòu)(Molecular Characterization)
This protein carries a polyhistidine tag at the C-terminus.
The protein has a calculated MW of 53.6 kDa. The protein migrates as 60-65 kDa when calibrated against Star Ribbon Pre-stained Protein Marker under reducing (R) condition (SDS-PAGE) due to glycosylation.
內(nèi)毒素(Endotoxin)
Less than 1.0 EU per μg by the LAL method.
純度(Purity)
>95% as determined by SDS-PAGE.
制劑(Formulation)
Lyophilized from 0.22 μm filtered solution in PBS with trehalose as protectant.
Contact us for customized product form or formulation.
重構(gòu)方法(Reconstitution)
Please see Certificate of Analysis for specific instructions.
For best performance, we strongly recommend you to follow the reconstitution protocol provided in the CoA.
存儲(chǔ)(Storage)
For long term storage, the product should be stored at lyophilized state at -20°C or lower.
Please avoid repeated freeze-thaw cycles.
This product is stable after storage at: -20°C to -70°C for 12 months in lyophilized state;
-70°C for 3 months under sterile conditions after reconstitution.


背景(Background)
狂犬病病毒(RABV),學(xué)名狂犬病lyssavirus,是一種致命的嗜神經(jīng)病毒,可導(dǎo)致人類和動(dòng)物狂犬病。狂犬病病毒的宿主范圍極廣,最常通過動(dòng)物唾液傳播。在疾病進(jìn)展之前不進(jìn)行干預(yù),狂犬病是所有傳染病中病死率最高的。RABV包含一個(gè)單鏈負(fù)義RNA基因組,編碼五種結(jié)構(gòu)蛋白:核蛋白(N)、磷蛋白(P)、基質(zhì)蛋白(M)、糖蛋白(G)和RNA依賴性RNA聚合酶(L)。在這些病毒蛋白中,RABV糖蛋白(RABV-G)是介導(dǎo)病毒進(jìn)入的關(guān)鍵參與者,也是中和抗體的主要靶標(biāo),因此是疫苗和藥物設(shè)計(jì)的關(guān)鍵因素。
關(guān)鍵字: RABV;RABV糖蛋白;Glycoprotein G;ACRO;百普賽斯;
百普賽斯集團(tuán)ACROBiosystems Group(股票代碼:301080)是成立于2010年的跨國(guó)生物科技公司,是為全球生物醫(yī)藥、健康產(chǎn)業(yè)領(lǐng)域提供關(guān)鍵生物試劑產(chǎn)品及解決方案的行業(yè)平臺(tái)型基石企業(yè)。2021年在創(chuàng)業(yè)板上市。百普賽斯集團(tuán)業(yè)務(wù)遍布全球,橫跨亞洲、北美洲、歐洲,在中國(guó)、美國(guó)、瑞士等12個(gè)城市設(shè)有辦公室、研發(fā)中心及生產(chǎn)基地。目前累計(jì)服務(wù)客戶超6000家,與全球Top 20醫(yī)藥企業(yè)均建立了長(zhǎng)期、穩(wěn)定的合作伙伴關(guān)系。集團(tuán)旗下?lián)碛衅放艫CROBiosystems百普賽斯、bioSeedin柏思薈、Condense Capital墾拓資本和ACRODiagnostics百斯醫(yī)學(xué)等。