5-氟胞嘧啶|T0986

價格	￥291
包裝	500mg

最小起訂量	1mg
發(fā)貨地	上海
更新日期	2025-03-12

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產(chǎn)品詳情

中文名稱:5-氟胞嘧啶	英文名稱:Flucytosine
CAS:2022-85-7	品牌: TargetMol
產(chǎn)地: 美國	保存條件: store at low temperature \| Powder: -20°C for 3 years \| In solvent: -80°C for 1 year \| Shipping with blue ice./Shipping at ambient temperature.
純度規(guī)格: 99.83%	產(chǎn)品類別: 抑制劑
貨號: T0986

Product Introduction

Bioactivity

名稱	Flucytosine
描述	Flucytosine (NSC 103805) is a pyrimidine compound and a fluorinated cytosine analog exhibiting antifungal activity.
細胞實驗	J774.16 murine macrophage-like cells plated on 96-well tissue culture plates are incubated with 500 u/mL murine recombinant gamma-interferon overnight at 37 °C. The medium is then replaced with fresh medium containing gamma-interferon 500 μ/mL, LPS 3 mg/L, C. neoformans cells 1.6 × 104/well and Flucytosine 50 mg/L. Plates are incubated for 24 hours at 37 °C. Cell supernatants are collected and cells lysed by adding 0.1 mL sterile distilled water to each well, incubating at room temperature for 30 minutes, and then aspirating and ejecting the lysate with a pipette several times to complete cell disruption. Wells are rinsed with PBS (0.1 mL) and the cell supernatant, and lysate and rinse from each well are pooled, vortexed, diluted 1:50, vortexed again and spread on Sabouraud's dextrose agar for the cfu determination(Only for Reference)
激酶實驗	Microdilution method: The culture media used are RPMI 1640 with glutamine, without bicarbonate and phenol red, buffered with morpholinopropanesulfonic acid (MOPS) (0.165 M, pH 7.0). Two-fold serial dilutions of Flucytosine (0.06-64 μg/mL) are prepared and dispensed in 50 uL aliquot, in flat-bottom 96-well assay plates which are kept frozen at -70 °C in sealed plastic bags until used. The inoculum is prepared spectrophotometrically and standardized to a concentration of 1.0-5.0 × 103 cfu per mL. A 50 μL volume of this suspension is used to inoculate each well containing 50 μL of the double concentration of Flucytosine to be tested. Once inoculated, each well therefore contains 100 μL of broth favoured over 200 μL to facilitate the agitation of the plates prior to spectrophotometric reading. After an incubation period of 24 and 48 hours at 35 °C, the plates are agitated for 3 minutes at 900 r.p.m. with a shaker and the optical density of the growth in each well is determined with the use of an automatic plate reader set at 495 nm. The inhibitory concentration of IC50 is computed mathematically.
體外活性	在感染新型隱球菌的A/JCr小鼠中,Flucytosine和單抗2H1聯(lián)合處理效果比單獨給藥效果好,明顯降低肺部菌落形成.
體內(nèi)活性	Lucytosine（≥1.25 mg / L）抑制Sabouraud葡萄糖培養(yǎng)液中C. neoformans的生長。
存儲條件	store at low temperature \| Powder: -20°C for 3 years \| In solvent: -80°C for 1 year \| Shipping with blue ice./Shipping at ambient temperature.
溶解度	DMSO : 3.85 mg/mL (29.79 mM), Sonication is recommended. H2O : 5 mg/mL (38.73 mM), Sonication is recommended. Ethanol : < 1 mg/mL (insoluble or slightly soluble)
關(guān)鍵字	NSC-103805 \| NSC103805 \| Inhibitor \| inhibit \| Fungal \| Flucytosine \| DNA synthesis \| Antibiotic
相關(guān)產(chǎn)品	Doxycycline (hyclate) \| Penicillin G potassium \| Ampicillin \| Doxycycline \| Neomycin sulfate \| Terbinafine hydrochloride \| Sulfacetamide sodium \| Metronidazole \| EDTA copper(II) disodium salt \| Ampicillin sodium \| Sulfamethoxazole sodium \| Kanamycin sulfate
相關(guān)庫	經(jīng)典已知活性庫 \| 抗真菌庫 \| 已知活性化合物庫 \| 植物來源化合物庫 \| 臨床失敗化合物庫 \| 抗癌天然產(chǎn)物庫 \| FDA 上市藥物庫 \| 天然產(chǎn)物庫 \| 免疫/炎癥分子化合物庫 \| 高通量篩選天然產(chǎn)物庫 \| 抗癌臨床化合物庫 \| 抗感染天然產(chǎn)物庫

關(guān)鍵字： Ro 2-9915|||NSC 103805|||Fluorocytosine|||5-氟胞嘧啶|||5-Fluorocytosine|TargetMol

公司簡介

上海陶術(shù)生物科技有限公司為美國Target Molecule Corp. ( Target Mol ) 在上海建立的全資子公司。我們與美國波士頓、德國慕尼黑的同事一起，為北美、歐洲和亞洲從事藥物研發(fā)和生物學(xué)研究的科學(xué)家提供優(yōu)質(zhì)的產(chǎn)品和專業(yè)的服務(wù)。公司下設(shè)篩選事業(yè)部，化學(xué)事業(yè)部，生物事業(yè)部和新材料部。從虛擬篩選到實體化合物分子供應(yīng)；從商業(yè)化產(chǎn)品銷售到個性化定制合成；從對明確靶點的分子篩選到對明確分子的多靶點篩選，從高通量篩選到化學(xué)結(jié)構(gòu)優(yōu)化，我們都可以滿足您的科研用品及技術(shù)服務(wù)的需求。經(jīng)過在中國市場五年的精心耕耘，我們已成為篩選化合物領(lǐng)域優(yōu)秀的供應(yīng)商，為超過五百家學(xué)校和各類企業(yè)提供了品質(zhì)卓越的小分子化合物和藥物篩

成立日期	2013-04-18 （13年）	注冊資本	566.2651萬人民幣
員工人數(shù)	100-500人	年營業(yè)額	￥ 1億以上
主營行業(yè)	化學(xué)試劑,生物活性小分子	經(jīng)營模式	貿(mào)易,試劑,定制,服務(wù)

TargetMol中國（陶術(shù)生物）

VIP 13年

公司成立：13年
注冊資本：566.2651萬人民幣
企業(yè)類型：有限責任公司(自然人投資或控股)
主營產(chǎn)品：小分子抑制劑，藥物篩選化合物庫，天然產(chǎn)物，活性分子化合物等
公司地址：上海市閘北區(qū)江場三路28號4樓

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