LGR5產(chǎn)品信息
英文名稱:Leucine-rich repeat-containing G-protein coupled receptor 5
中文名稱:富含亮氨酸重復序列的G蛋白偶聯(lián)受體-5
靶點別稱:LGR5, GPR49, GPR67, G-protein coupled receptor 49, G-protein coupled receptor 67, G-protein coupled receptor HG38, Leucine-rich repeat-containing G-protein coupled receptor 5
物種:Human / Cynomolgus
屬性:Protein
標記:Unconjugated
內(nèi)毒素(Endotoxin)
Less than 1.0 EU per μg by the LAL method.
純度(Purity)
>90% as determined by SDS-PAGE.
制劑(Formulation)
Lyophilized from 0.22 μm filtered solution in PBS, pH7.4 with trehalose as protectant.
Contact us for customized product form or formulation.
重構(gòu)方法(Reconstitution)
Please see Certificate of Analysis for specific instructions.
For best performance, we strongly recommend you to follow the reconstitution protocol provided in the CoA.
存儲(Storage)
For long term storage, the product should be stored at lyophilized state at -20°C or lower.
Please avoid repeated freeze-thaw cycles.
This product is stable after storage at:
1. -20°C to -70°C for 12 months in lyophilized state;
2. -70°C for 3 months under sterile conditions after reconstitution.
LGR5分子背景
LGR5(也稱為GPR49)是GPCR a類視紫紅質(zhì)樣家族的七跨膜蛋白。LGR5和LGR4以高親和力結(jié)合R-敏感蛋白,并通過增強Wnt誘導的LRP6磷酸化來介導Wnt/β-catenin信號傳導的增強。LGR5/RSPO復合物可以通過中和兩種跨膜E3連接酶RNF43和ZNRF3來促進Wnt信號傳導。
關(guān)鍵字: LGR5;LGR5蛋白;GPR49;GPR49蛋白;GPR67;
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