中文名：克唑替尼
英文名：Crizotinib
中文別名：克里唑替尼|3-[(1R)-1-(2,6-二氯-3-氟苯基)乙氧基]-5-[1-(4-哌啶)-1H-吡唑-4-基]-2-吡啶胺|克唑替尼|(R)-3-[1-(2,6-二氯-3-氟 - 苯基)-乙氧基]-5-(1-哌啶-4-基-1H-吡唑-4-基)-吡啶-2-基胺|克唑替尼|PF02341066|PF 2341066
英文別名：Crizotinib|877399-52-5|Xalkori|(R)-crizotinib|PF-02341066|PF-2341066|PF 2341066|(R)-3-(1-(2,6-dichloro-3-fluorophenyl)ethoxy)-5-(1-(piperidin-4-yl)-1H-pyrazol-4-yl)pyridin-2-amine|Crizotinib (PF-02341066)|crizotinibum|3-[(1R)-1-(2,6-Dichloro-3-fluoropheny
純度：≥99%
貨號：C137735
包裝：1g、5g、25g
Cas號：877399-52-5
存儲溫度：2-8°C儲存
產品介紹：
PF-2341066 shows inhibition of Met phosphorylation in mIMCD3 mouse of MDCK canine epithelial cells with an IC50 of 5 nM and 20 nM, respectively, as well as NCI-H69 and HOP92 cells, with an IC50 of 13 nM and 16 nM, respectively. PF-2341066 shows a near-equivalent IC50 of 24 nM against the nucleophosmin (NPM)-anaplastic lymphoma kinase (ALK) oncogenic fusion varient of the ALK RTK expressed by the KARPAS299 human anaplastic large-cell lymphoma (ALCL) cell line. PF-2341066 supresses human GTL-16 gastric carcinoma cell growth with an IC50 of 9.7 nM. PF-2341066 induces apoptosis in GTL-16 cells with an IC5050 of 30 nM.
A Met inhibitor effective against various cell lines
Crizotinib has been used:
· to investigate its effects on hepatocyte growth factor receptor (c-Met) expression, proliferation and apoptosis
· to block neurotrophic tyrosine kinase receptor type 1 (NTRK1) activity in epithelial cells
· to restore sensitivity to erlotinib
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關鍵字： 克里唑替尼;3-[(1R)-1-(2,6-二氯-3-氟苯基)乙氧基]-5-[1-(4-哌啶)-1H-吡唑-4-基]-2-吡啶胺;克唑替尼;(R)-3-[1-(2,6-二氯-3-氟 - 苯基)-乙氧基]-5-(1-哌啶-4-基-1H-吡唑-4-基)-吡啶-2-基胺
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