Rabbit Anti-GRM1 + GRM5 Polyclonal Antibody
DATASHEET
Host:Rabbit
Target Protein:GRM1 + GRM5
IR:Immunogen Range:501-600/1194
Clonality:Polyclonal
Isotype:IgG
Entrez Gene:2911
Swiss Prot:Q13255
Source:KLH conjugated synthetic peptide derived from human MGLUR1 + MGLUR5:501-600/1194
Purification:affinity purified by Protein A
Storage:0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
Background:Glutamate is the main excitatory neurotransmitter in the brain. For many years it had been considered to act only on the ligand-gated receptor channels-termed NMDA, AMPA and kainite receptors that are involved in the fast excitatory synaptic transmission. Recently, glutamate has been shown to regulate enzymes producing second messengers via specific receptors coupled to G-proteins. These receptors are called metabotropic glutamate receptors. In expression systems, Group-I receptors stimulate phospholipase C as revealed by an increase in phosphoinositide turnover and calcium release from internal stores. Group-II and -III receptors are coupled to the inhibition of adenylyl cyclase. The Group-I receptors include Metabotropic Glutamate Receptor 5 and Metabotropic Glutamate Receptor 1a. The Group-II receptors in include mGluR2 and mGluR3.
Size:50ul
Concentration:1mg/ml
Applications:WB(1:500-2000)
ELISA(1:5000-10000)
Cross Reactive Species:Human
Mouse
Rat
Chicken
Dog
Pig
Cow
Horse
Sheep
僅供科研使用。不能用于人和動物治療等其它臨床診斷用！
關(guān)鍵字： GRM1 + GRM5;MGLUR1+MGLUR5;GPRC1A;GPRC1E;GRM1A;Metabotropic glutama;MGLUR5;GRM1_HUMAN;
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