Rabbit Anti-Phospho-MYPT1 (Thr696) Polyclonal Antibody
DATASHEET
Host:Rabbit
Target Protein:Phospho-MYPT1 (Thr696)
IR:Immunogen Range:RS(p-T)QG
Clonality:Polyclonal
Isotype:IgG
Entrez Gene:4659
Swiss Prot:O14974
Source:KLH conjugated synthesised phosphopeptide derived from human MYPT1 around the phosphorylation site of Thr696:RS(p-T)QG
Purification:affinity purified by Protein A
Storage:0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
Background:Myosin phosphatase regulates the interaction of actin and myosin downstream of the guanosine triphosphatase Rho. The small guanosine triphosphatase Rho is implicated in myosin light chain (MLC) phosphorylation, which results in contraction of smooth muscle and interaction of actin and myosin in non muscle cells. The guanosine triphosphate (GTP) bound, active form of RhoA (GTP.RhoA) specifically interacted with the myosin binding subunit (MBS) of myosin phosphatase, which regulates the extent of phosphorylation of MLC. Rho associated kinase (Rho kinase), which is activated by GTP. RhoA, phosphorylated MBS and consequently inactivated myosin phosphatase. Overexpression of RhoA or activated RhoA in NIH 3T3 cells increased phosphorylation of MBS and MLC. Therefore Rho appears to inhibit myosin phosphatase through the action of Rho kinase.
Size:50ul
Concentration:1mg/ml
Applications:WB(1:500-2000)
Flow-Cyt(1μg /Test)
Cross Reactive Species:Human
Mouse
Rat
Chicken
Dog
Cow
Horse
Rabbit
僅供科研使用。不能用于人和動物治療等其它臨床診斷用！
關鍵字： Phospho-MYPT1 (Thr69;MYPT1 (Phospho Thr69;MYPT1 ;MGC133042;MBS;M130;MYPT1;MYPT1_HUMAN;
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