Host:Rabbit
Target Protein:Phospho-Tuberin (Ser1418)
IR:Immunogen Range:AR(p-S)QS
Clonality:Polyclonal
Isotype:IgG
Entrez Gene:7249
Swiss Prot:P49815
Source:KLH conjugated Synthesised phosphopeptide derived from human Tuberin around the phosphorylation site of Ser1418:AR(p-S)QS
Purification:affinity purified by Protein A
Storage:0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
Background:Tuberin, or TSC2 (Tuberous sclerosis complex), is implicated as a tumor suppressor. It may function in vesicular transport, and may also play a role in the regulation of cell growth arrest and in the regulation of transcription mediated by steroid receptors. Interaction between hamartin (TSC1) and tuberin may facilitate vesicular docking. It specifically stimulates the intrinsic GTPase activity of the Ras related protein RAP1A and RAB5, suggesting a possible mechanism for its role in regulating cellular growth. Mutations in tuberin lead to constitutive activation of RAP1A in tumors. At least three isoforms of Tuberin exist.
Size:50ul
Concentration:1mg/ml
Applications:ELISA(1:5000-10000)
IHC-P(1:100-500)
IHC-F(1:100-500)
Flow-Cyt(1ug/Test)
IF(1:100-500)
Cross Reactive Species:Human
Mouse
Rat
Chicken
Dog
Pig
Cow
Horse
本品僅供科研使用。不能用于人和動物治療等其它臨床診斷用！
關(guān)鍵字： TSC2;FLJ43106;LAM;TSC2_HUMAN;TSC4;Phospho-Tuberin;Tuberous sclerosis 2; P-TSC2;
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