Product Name：Cenupatide
CAS No.：1006388-38-0
Synonyms：Ac-Arg-Aib-Arg-α(Me)Phe-NH2；抑制劑Cenupatide
Catalog No.：218P027
Brand：HongTide（上海鴻肽）
Description：Cenupatide是一種尿激酶纖溶酶原激活物受體 (uPAR) 抑制劑候選藥物，是一條由4個(gè)氨基酸組成的直鏈小分子多肽，序列中含有兩個(gè)非天然氨基酸。Cenupatide抑制uPAR與甲酰肽受體(FPR)的結(jié)合可以改善鏈脲佐菌素(STZ)誘導(dǎo)的糖尿病大鼠模型中的腎臟損傷。實(shí)驗(yàn)發(fā)現(xiàn)Cenupatide可恢復(fù)STZ誘導(dǎo)的uPA水平和活性上調(diào)，而足細(xì)胞上的uPAR和(s)uPAR不受影響。同事在腎小球中，Cenupatide能抑制FPR2表達(dá)，表明該藥物可能作用于下游uPAR，并恢復(fù)了αvβ3整合素/Rac-1 途徑的活性增加，表明uPAR在調(diào)節(jié)足細(xì)胞功能中的主要作用。
Cenupatide is a candidate drug for urokinase plasminogen activator receptor (uPAR) inhibitor. It is a straight-chain small-molecule peptide composed of four amino acids and contains two unnatural amino acids in its sequence. Cenupatide inhibits the binding of uPAR to formyl peptide receptor (FPR), which can improve the renal damage in the model of streptozotocin (STZ) - induced diabetes rats. It was found that Cenupatide could restore the up-regulation of uPA level and activity induced by STZ, while uPAR and (s) uPAR on podocytes were not affected. In the glomerulus, Cenupatide can inhibit the expression of FPR2, indicating that the drug may act on the downstream uPAR and recover α v β 3 The increased activity of integrin/Rac-1 pathway indicates that uPAR plays a major role in regulating podocyte function.
Purity (HPLC) ≥98.0%
Single impurity≤2%
Peptide content≥75.0%
Amino Acid Composition≤±15%
Bacterial Endotoxins≤50EU/mg
Solubility：H2O/DMSO
Vacuum-packed with aluminum foil bag or transparent bag.Various weights can be packed according to your requirements.
Storage:Cool dry place( Store at -20°C, away from the light)
Remark:For Research Use Only. Not for human use.
Sequence(1-letter code) | Ac-R-Aib-R-N-Me-Phe-NH2 |
Sequence(3-letter code) | Ac-Arg-Aib-Arg-N-Me-Phe-NH2 |
Peptide Structure | 
|
Molecular Formula | C28H47N11O5 |
Molecular Weight | 617.75 |
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關(guān)鍵字： 1006388-38-0;Cenupatide;抑制劑Cenupatide;多肽;抑制劑多肽;
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