產品屬性：
產品名稱 | 規(guī)格 | CAS號 | 型號 |
Lipoxygenin | 1 mg 5 mg 10 mg | 2247911-68-6 | EY-Y0164306 |
Cas No.2247911-68-6
別名 N/A
化學名 N/A
分子式 C24H22N2O4
分子量 402.4
溶解度 DMF: 30mg/mL,DMSO: 30mg/mL,DMSO:PBS (pH 7.2) (1:1): 0.5mg/mL
儲存條件 Store at -20°C
General tips For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping Condition Evaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
產品描述：
Lipoxygenin is an inhibitor of 5-lipoxygenase (5-LO) with an IC50 value of 5 μM for inhibition of 5-LO product synthesis in isolated human granulocytes stimulated with the cation ionophore A23187 .1 It inhibits hedgehog-dependent signaling in Shh-LIGHT2 cells and TGF-β-, activin A-, bone morphogenic protein (BMP)-, or Wnt-dependent signaling in HEK293T cells (IC50s = 9.3, 3.2, 8.2, 9.6, and 3.7 μM, respectively, in luciferase reporter assays). Lipoxygenin (5 and 10 μM) increases levels of troponin T (TnnT), a marker of cardiomyocyte differentiation, in human induced pluripotent stem cells (iPSCs) stimulated with BMP4 and the glycogen synthase kinase 3 (GSK3) inhibitor CHIR99021 .
1.Brand, S., Roy, S., Schr?der, P., et al.Combined proteomic and in silico target identification reveal a role for 5-lipoxygenase in developmental signaling pathwaysCell Chem. Biol.25(9)1095-1106(2018)
關鍵字： 2247911-68-6;C24H22N2O4;Lipoxygenin;
上海一研生物科技有限公司Shanghai yiyan bio-technology Co. Ltd.主要從事免疫學、分子生物學和常規(guī)生化試劑等為一體的科研產品銷售企業(yè)，公司自成立以來，秉承""全心全意服務于科研工作者""的企業(yè)理念，立足生物科技領域，運用生物技術和科研試劑，發(fā)展現代生物科技，為各類大中小醫(yī)院及其它醫(yī)療機構、高等院校、科研院所、企事業(yè)單位提供優(yōu)質的產品，服務生物科技領域的科學研究人員。
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