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Bunaprolast (U66858),Bunaprolast (U66858)
  • Bunaprolast (U66858),Bunaprolast (U66858)

99107-52-5Bunaprolast (U66858)

價格 詢價
包裝 1盒
最小起訂量 1盒
發(fā)貨地 上海
更新日期 2025-02-06
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產(chǎn)品詳情

中文名稱:Bunaprolast (U66858)英文名稱:Bunaprolast (U66858)
CAS:99107-52-5品牌: 一研
保存條件: Store at -20°C產(chǎn)品類別: 抑制劑
Cas : 99107-52-5
2025-02-06 Bunaprolast (U66858) Bunaprolast (U66858) 1盒/RMB 一研 Store at -20°C 抑制劑

產(chǎn)品屬性:

產(chǎn)品名稱

規(guī)格

CAS

型號

Bunaprolast (U66858)

1mg 5mg 10mg 20mg

99107-52-5

EY-Y0163973

Cas No.99107-52-5

別名 N/A

化學名 N/A

分子式 C17H20O3

(-)-BAY-1251152.png

分子量 272.34

溶解度 Soluble in DMSO

儲存條件 Store at -20°C
General tips  For obtaining a higher solubility , please warm the tube at 37 and shake it in the ultrasonic bath for a while.
Shipping Condition     Evaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
產(chǎn)品描述:
Bunaprolast (U66858) is a potent inhibitor of LTB4 production in human whole blood. Bunaprolast (U66858) also exhibits significant inhibition of lipoxygenase and TXB2 release.

Bunaprolast (U-66,858) undergoes deacetylation to an initial metabolite with similar pharmacological potency. The inhibitory effects of the semi-quinone Bunaprolast and its metabolite U-68,244 on the ionophore-induced formation of leukotriene B4 (LTB4) are examined in human whole blood (WB). Preincubation of Bunaprolast and U-68,244 for 1 min prior to challenge of blood with calcium ionophore A23187 results in IC50s of 1080±644 and 820±442 nM, respectively. After 60 min preincubation, IC50s are 250±85 and 270±79 nM. The activity of the lipoxygenase inhibitor AA-861 in this system is similar to that of Bunaprolast, while vitamin K and the sulphate conjugate of Bunaprolast show significant inhibition of LTB4 release only at micromolar concentrations. Bunaprolast exhibits significant inhibition of thromboxane A2 release (p<0.02) in a comparative study with the known cyclooxygenase (CO) inhibitor Flurbiprofen[1].

The IgE-mediated hypersensitivity to Ascaris antigen in reactor rhesus primates is used to assess the pharmacologic profile of Bunaprolast (U-66,858). When Bunaprolast is given by the oral route, it shows dose-related inhibition of resistance (RL) and compliance (Cdyn) changes. When Bunaprolast is given by the aerosol route, it shows dose independent inhibition. In 15 animals, aerosols (52±32 to 53±10% for RL, p=0.05 and 45±19 to 28±19% Cdyn inhibitions, p=0.05) for 5.0-0.1% aerosol. By the oral route, inhibition is seen at 1-4 h following administration. In 5 animals, oral doses of 10 and 5 mg/kg inhibit (RL by 98±2 to 78±1.5%, p=0.01 and Cdyn by 75±17 to 60.9±9.1%, p=0.05) by 10 and 5 mg/kg Bunaprolast, respectively[2].

[1]. Summers JA, et al. Lipoxygenase inhibitory activity of U-66,858 and its deacetylated metabolite U-68,244 in human whole blood. Agents Actions. 1994 Mar;41(1-2):32-6. [2]. Johnson HG, et al. Activity of a novel hydroquinone inhibitor of leukotriene synthesis (U-66,858) in the rhesus monkey Ascaris reactor. Int Arch Allergy Appl Immunol. 1988;87(2):204-7.


關鍵字: 99107-52-5;C17H20O3;Bunaprolast (U66858);

公司簡介

上海一研生物科技有限公司Shanghai yiyan bio-technology Co. Ltd.主要從事免疫學、分子生物學和常規(guī)生化試劑等為一體的科研產(chǎn)品銷售企業(yè),公司自成立以來,秉承""全心全意服務于科研工作者""的企業(yè)理念,立足生物科技領域,運用生物技術和科研試劑,發(fā)展現(xiàn)代生物科技,為各類大中小醫(yī)院及其它醫(yī)療機構、高等院校、科研院所、企事業(yè)單位提供優(yōu)質(zhì)的產(chǎn)品,服務生物科技領域的科學研究人員。 公司具有對普通貨物、冷藏及冷凍倉庫的存儲、包裝及運輸能力。 公司將始終堅持信譽立業(yè)、以人為本、質(zhì)量保證、誠信服務的宗旨,不斷拼搏,開拓進取,與各界朋友攜手共創(chuàng)美好未來。
成立日期 2014-06-05 (11年) 注冊資本 100
員工人數(shù) 50-100人 年營業(yè)額 ¥ 100萬以內(nèi)
主營行業(yè) 生化試劑,抗體,細胞培養(yǎng),分子生物學,免疫安全 經(jīng)營模式 工廠,試劑
  • 上海一研生物科技有限公司
VIP 3年
  • 公司成立:11年
  • 注冊資本:100
  • 企業(yè)類型:營業(yè)執(zhí)照
  • 主營產(chǎn)品:、ELISA試劑盒、PCR檢測試劑盒、生化檢測試劑盒、標準品、抗體、細胞等
  • 公司地址:上海市閔行區(qū)莘福路2號樓
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99107-52-5Bunaprolast (U66858)相關廠家報價

產(chǎn)品名稱 價格   公司名稱 報價日期
¥12600
VIP3年
TargetMol中國(陶術生物)
2024-12-12
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