別名
(R)-N-Fmoc-α-(7-Octenyl)alanine,Fmoc-(R)-2-(7-octenyl)alanine,Fmoc-(R)-2-amino-2-methyl-dec-6-enoic acid
應用
Olefinic alpha-methyl amino acid for peptide stapling. Upon incorporation of this amino acid into a peptide, along with another of the same or derivative with a different length of the olefinic side chain, the two can be ′stapled′ via a ring closing metathesis reaction with Grubb′s catalyst (product # 579726). The resulting stapled peptide macrocycle has been shown to stabilize the alpha-helical structure of peptides, which can lead to favorable biological characteristics such as increased proteolytic stability and cellular uptake.
Sigma-Aldrich西格瑪奧德里奇(上海)貿(mào)易有限公司
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