Name: Acalabrutinib (ACP-196)
CAS#: 1420477-60-6 (free base)
Chemical Formula: C26H23N7O2
Exact Mass: 465.19132
Molecular Weight: 465.52
Elemental Analysis: C, 67.08; H, 4.98; N, 21.06; O, 6.87
Description: Acalabrutinib, also known as ACP-196, is an orally available inhibitor of Bruton’s tyrosine kinase (BTK) with potential antineoplastic activity. Upon administration, ACP-196 inhibits the activity of BTK and prevents the activation of the B-cell antigen receptor (BCR) signaling pathway. This prevents both B-cell activation and BTK-mediated activation of downstream survival pathways. This leads to an inhibition of the growth of malignant B cells that overexpress BTK. BTK, a member of the src-related BTK/Tec family of cytoplasmic tyrosine kinases, is overexpressed in B-cell malignancies; it plays an important role in B lymphocyte development, activation, signaling, proliferation and survival.
Synonym: ACP-196; ACP196; ACP 196; Acalabrutinib
IUPAC/Chemical Name: (S)-4-(8-amino-3-(1-(but-2-ynoyl)pyrrolidin-2-yl)imidazo[1,5-a]pyrazin-1-yl)-N-(pyridin-2-yl)benzamide
InChi Key: WDENQIQQYWYTPO-IBGZPJMESA-N
InChi Code: InChI=1S/C26H23N7O2/c1-2-6-21(34)32-15-5-7-19(32)25-31-22(23-24(27)29-14-16-33(23)25)17-9-11-18(12-10-17)26(35)30-20-8-3-4-13-28-20/h3-4,8-14,16,19H,5,7,15H2,1H3,(H2,27,29)(H,28,30,35)/t19-/m0/s1
SMILES Code: O=C(NC1=NC=CC=C1)C2=CC=C(C3=C4C(N)=NC=CN4C([C@H]5N(C(C#CC)=O)CCC5)=N3)C=C2
Appearance: Yellow solid powder
Purity: >98% (or refer to the Certificate of Analysis)
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility: Soluble in DMSO, not in water
Shelf Life: >2 years if stored properly
Drug Formulation: This drug may be formulated in DMSO
Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code: 2934.99.9001
關(guān)鍵字： 阿卡替尼;Acalabrutinib;1420477-60-6;
北京百奧創(chuàng)新科技有限公司是一家專注于生命科學(xué)的科技企業(yè)，由在國內(nèi)科研試劑領(lǐng)域有著豐富從業(yè)經(jīng)驗(yàn)的技術(shù)團(tuán)隊(duì)和管理團(tuán)隊(duì)組建而成，專營進(jìn)口生物試劑，科學(xué)儀器，實(shí)驗(yàn)消耗品等。公司與諸多國外品牌簽下代理，RD、Abcam、CST、Genetex、Biolegend、ebioscience、polypure、polyplus、Bethyl、Novus等，能為廣大科研用戶提供數(shù)萬種試劑、儀器和實(shí)驗(yàn)消耗品。
公司將不斷把上優(yōu)質(zhì)的產(chǎn)品引入國內(nèi)市場，滿足客戶的需求，公司也將緊跟生命科學(xué)的發(fā)展，為廣大科研工作者探索生命科學(xué)的奧秘奉獻(xiàn)綿薄之力！