• 中文名稱

• 扎伊爾埃博拉病毒 GP 蛋白兔多克隆抗體

• 英文名字

• Rabbit polyclonal antibody to Zaire Ebolavirus GP protein

• 供應(yīng)商

• Icosagen

• 產(chǎn)品貨號(hào)

• A2-100-100

• 背景資料

• GP1 is responsible for binding to the receptors on target cells. Interacts with CD209/DC-SIGN and CLEC4M/DC-SIGNR which act as cofactors for virus entry into the host cell. Binding to CD209 and CLEC4M, which are respectively found on dendritic cells (DCs), and on endothelial cells of liver sinusoids and lymph node sinuses, facilitate infection of macrophages and endothelial cells. These interactions not only facilitate virus cell entry, but also allow capture of viral particles by DCs and subsequent transmission to susceptible cells without DCs infection (trans infection). GP2 acts as a class I viral fusion protein. Under the current model, the protein has at least 3 conformational states: pre-fusion native state, pre-hairpin intermediate state, and post-fusion hairpin state. During viral and target cell membrane fusion, the coiled coil regions (heptad repeats) assume a trimer-of-hairpins structure, positioning the fusion peptide in close proximity to the C-terminal region of the ectodomain. The formation of this structure appears to drive apposition and subsequent fusion of viral and target cell membranes.GP1,2 mediates endothelial cell activation and decreases endothelial barrier function. Mediates activation of primary macrophages. At terminal stages of the viral infection, when its expression is high, GP1,2 down-modulates the expression of various host cell surface molecules that are essential for immune surveillance and cell adhesion. Down-modulates integrins ITGA1, ITGA2, ITGA3, ITGA4, ITGA5, ITGA6, ITGAV and ITGB1. GP1,2 alters the cellular recycling of the dimer alpha-V/beta-3 via a dynamin-dependent pathway. Decrease in the host cell surface expression of various adhesion molecules may lead to cell detachment, contributing to the disruption of blood vessel integrity and hemorrhages developed during Ebola virus infection (cytotoxicity). (Ebola GP1 and 2 functions, UniProt).

• 應(yīng)用類型

• ELISA, WB, IF

• 免疫原

• Ebolavirus GP protein

• 來源宿主

• 兔

• 反應(yīng)性

• Zaire Ebolavirus GP protein

• 保存建議

• Store at +4°C upon receipt. As product is (NH4)2SO4 precipitate, mix well by pipetting or vortexing prior use.

• 其他

• Icosagen AS成立于1999年，總部位于愛沙尼亞，提供一系列現(xiàn)成產(chǎn)品，如抗體、蛋白質(zhì)、ELISA試劑盒等，以及天然橡膠過敏原檢測(cè)和食品質(zhì)量控制領(lǐng)域的質(zhì)量控制服務(wù)。產(chǎn)品涵蓋的應(yīng)用領(lǐng)域有：神經(jīng)生物學(xué)，病毒學(xué)，心臟標(biāo)志物，細(xì)胞因子，炎癥，過敏原等。Icosagen提供用于診斷和研究的重組抗體和抗原。Icosagen將現(xiàn)代重組技術(shù)和20年的制藥經(jīng)驗(yàn)引入診斷領(lǐng)域，以開發(fā)和生產(chǎn)高質(zhì)量的試劑。利用Icosagen的專利系列，開發(fā)和生產(chǎn)高親和力和特異性的單克隆和多克隆抗體。Icosagen已通過ISO 9001:2015認(rèn)證，并遵循GLP指南。

湖北艾普蒂生物工程有限公司（簡(jiǎn)稱：艾普蒂）由在國(guó)內(nèi)科研試劑領(lǐng)域有著十幾年從業(yè)經(jīng)驗(yàn)的專業(yè)技術(shù)團(tuán)隊(duì)和企業(yè)管理團(tuán)隊(duì)組建而成，專門從事以抗體、蛋白、細(xì)胞、化學(xué)品為核心的試劑產(chǎn)品研發(fā)與銷售。

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