中文名稱
【MMP 9】重組人堿性金屬蛋白酶-9
英文名字
Recombinant Human Matrix Metalloproteinase-9
供應(yīng)商
ProSpec
產(chǎn)品貨號
ENZ-438
產(chǎn)品報價
¥800/2ug ¥2080/10ug ¥77280/1mg
產(chǎn)品說明書
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購買方式
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產(chǎn)品新聞
背景資料
Matrix metalloproteinases are a family of zinc and calcium-dependent endopeptidases that break down extracellular matrix proteins. The MMP9 is secreted as a 92kDa zymogen. Cleavage of ProMMP-9 results in the active enzyme, having a molecular weight of approximately 82kDa. MMP9 is composed of the following domains: a gelatin-binding domain consisting of three fibronectin type II units, a catalytic domain containing the zinc-binding site, a proline-rich type V collagen-homologous domain and a hemopexin-like domain. MMP9 is produced by the several cell types: monocytes, macrophages, neutrophils, keratinocytes, fibroblasts, osteoclasts and endothelial cells. MMP9 is involved in inflammatory responses, tissue remodeling, wound healing, tumor growth and metastasis. MMP9 may also play an important part in local proteolysis of the extracellular matrix and in leukocyte migration, as well as in bone osteoclastic resorption. MMP9 cleaves type IV and type V collagens into large C-terminal three quarter fragments and shorter N-terminal one quarter fragments. MMP9 can also degrade fibronectin but not laminin or Pz-peptide.MMP9 defects may be a cause of susceptibility to intervertebral disc disease(IDD), also known as lumbar disk herniation(LDH).
序列
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來源宿主
大腸桿菌中重組表達(dá)
溶解建議
提供的人基質(zhì)金屬蛋白酶-9(MMP 9)產(chǎn)品為過濾滅菌的透明溶液;其中人基質(zhì)金屬蛋白酶-9(MMP 9)產(chǎn)品溶解于20mM Tris-HCl pH 8.0,50%甘油溶液中.
保存建議
人基質(zhì)金屬蛋白酶-9(MMP 9)溶液可以在4℃冷藏保存2-4周;如果想延長保存時間,建議分裝后置于-20℃凍存.請避免反復(fù)凍融.
其他
ProSpec 是一家全球著名細(xì)胞因子蛋白生產(chǎn)和研發(fā)的公司,具有20多年的生產(chǎn)經(jīng)驗,專注于蛋白(重組及合成)生產(chǎn)研發(fā)。我們的核心產(chǎn)品包括:干擾素、白介素、骨蛋白、腫瘤壞死因子、成纖維生長因子、瘦素、干細(xì)胞因子、催乳素、表皮生長因子、胰島素樣生長因子、神經(jīng)生長因子、集落刺激因子、激素、酶、病毒抗原以及各種重組蛋白等。 領(lǐng)先的生產(chǎn)工藝和規(guī)模使其可以提供毫克到克級蛋白,價格優(yōu)于同類公司。絕大部分產(chǎn)品是天然成熟型蛋白,而不含有標(biāo)簽蛋白。考慮到大部分研究者希望能更靈活地配制蛋白溶液,ProSpec-Tany絕大部分產(chǎn)品沒有添加保護(hù)劑或鹽,這就對工藝提出了更高的要求。同時,ProSpec-Tany絕大部分產(chǎn)品為凍干粉,因此易于運輸和保存。
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