中文名稱：脫羧肌肽
同義詞：CARCININE 二鹽酸鹽
產(chǎn)品編號：PR0146006
CAS號：57022-38-5
分子式：C8H16Cl2N4O
重量：255.144839286804
介紹：
眾所周知，肌肽是一種天然存在的二肽，具有極好的清除自由基和抗糖基化作用。
Decarboxy Carnosine HCL是由肌肽脫羧而得，不僅延續(xù)了肌肽清除自由基和抵抗糖基化的能力，而且改善了自身的性質，在特定的生理環(huán)境下比肌肽更穩(wěn)定。
英文名稱：Carcinine dihydrochloride
CAS號：57022-38-5
分子重量：255.14
MF：C8H14N4O·2HCl
生物活性
Carcinine（β-丙氨酰組胺）是一種選擇性組胺 H3 拮抗劑，對 H3 的選擇性是 H2 和 H1 的 100-1000 倍，它還具有抗氧化劑和化學伴侶的作用，可減少蛋白質的非酶糖化并維持天然折疊的蛋白質。
機制
1.清除自由基，抗氧化
脫羧肌肽具有捕獲羥基自由基、單質氧自由基和過氧化氫自由基的作用，能抑制非金屬離子引起的脂質氧化，穩(wěn)定保護細胞膜。
2. 抗糖化
皮膚發(fā)生糖基化，使膠原蛋白逐漸失去彈性，在皮膚表面形成皺紋，膚色變黃。
脫羧肌肽通過兩個不同的靶點抑制結構蛋白的糖基化，保護膠原蛋白和彈性蛋白。
功能：
1.清除自由基，抗氧化。
2. 抗糖基化。
3.提亮膚色，去除黃皮。
4. 抗紫外線和污染物。
5、防止皮膚過早老化，保持皮膚年輕狀態(tài)。
應用：
可添加到美容護膚品中，如乳液、面膜、早晚霜、眼霜、眼部精華、面部精華、肌底液、爽膚水、眼膜、凝膠等。
建議用量：
0.1% 在乳液和凝膠中。
安全：
體內外試驗均表明脫羧肌肽不會引起任何細胞毒性、皮膚刺激、過敏和眼睛刺激。
包裝：
1公斤/袋、10公斤/桶或25公斤/桶。
貯存：
密封、陰涼、清潔處保存，避強光。
保質期：24 個月。
English name: Carcinine dihydrochloride
Synonym: Decarboxy Carnosine HCL
Product ID: PR0146006
CAS NO.: 57022-38-5
Formula: C8H16Cl2N4O
Weight: 255.144839286804
Introduction:
As we all know, Carnosine is a naturally occurring dipeptide with excellent free radical scavenging and anti-glycosylation affection.
Decarboxy Carnosine HCL is derived from carnosine by decarboxylation, which not only continues carnosine's ability to scavenge free radicals and resist glycosylation, but also improves its own properties and is more stable than carnosine in a specific physiological environment.
English Name: Carcinine dihydrochloride
CAS No: 57022-38-5
MW: 255.14
MF: C8H14N4O·2HCl
Biological activity
Carcinine (β-alanyl histamine) is a selective histamine H3 antagonist, 100-1000-fold selective for H3 over H2 and H1, that also functions as an antioxidant and as a chemical chaperone to reduce non-enzymatic glycation of proteins and maintain native folding of proteins.
Mechanism
1. Scavenging free radicals, anti-oxidation
Decarboxylated carnosine has the effect of capturing hydroxyl radicals, elemental oxygen and hydrogen peroxide radicals, it can inhibit lipid oxidation caused by non-metallic ions and stably protect cell membranes.
2. Anti-glycation
Glycosylation takes place on the skin, causing collagen to gradually lose its elasticity, forming wrinkles on the skin surface, and yellowing complexion.
Decarboxylated carnosine inhibits of structural proteins glycosylation through two different targets, protecting collagen and elastin.
Function:
1. Scavenging free radicals and anti-oxidation.
2. Anti-glycosylation.
3. Brightening skin tone, removing yellow skin.
4. UV and pollutants resistance.
5. Prevent premature skin aging and maintain skin youthful state.
Application:
It Can be added to beauty skin care products, such as lotion, mask, morning and evening cream, eye cream, eye essence, facial essence, muscle foundation, toner, eye mask, gel etc.
Suggestion Dosage:
0.1% in the lotion and gel.
Security:
Both in vivo and in vitro tests showed that decarboxylated carnosine did not cause any cytotoxicity, skin irritation, allergy and eye irritation.
Packing:
1kg/Bag, 10kg/Drum or 25kgs/Drum.
Storage:
Keep in Sealed, Cool, clean place, and Avoid strong Light.
Shelf Life: 24 months.
關鍵字： Decarboxylation ;脫羧肌肽;Propanamide;Decarboxylation ;dihydrochloride;
迪克曼致力于功能性化合物研發(fā)，包括生物抑制劑、熒光探針與染料、抗體佐劑、保健食品和化妝品原料、藥物中間體等，并提供定制合成、合同研究及大包裝服務。