YM-58790 NEW
| Price | $147 | $323 | $516 |
| Package | 1mg | 5mg | 10mg |
| Min. Order: | |
| Supply Ability: | 10g |
| Update Time: | 2024-11-15 |
Product Details
| Product Name: YM-58790 | CAS No.: 168830-70-4 |
| Purity: 99% | Supply Ability: 10g |
| Release date: 2024/11/15 |
Product Introduction
Bioactivity
| 名稱(chēng) | YM-58790 |
| 描述 | YM-58790 free base is a potent mAChR antagonist that inhibits M1 mAChR, M2 mAChR, and M3 mAChR with Ki values of 28 nM, 260 nM, and 15 nM, respectively. It inhibits reflex rhythmic bladder contractions in rats by inhibiting bladder pressurization. |
| 體外活性 | YM-58790 free base (compound 18b) (0-1 μM) potently inhibits urinary bladder contraction with minimal impact on bradycardia. In vitro, YM-58790 selectively antagonizes urinary bladder contraction without significantly affecting salivary secretion. [1] |
| 體內(nèi)活性 | YM-58790 free base (3 mg/kg, i.v.) exhibits no impact on oxotremorine-induced tremor in mice.[1] At 6.0 mg/kg, i.v., YM-58790 free base shows limited M1 and M2 antagonistic effects on McN-A343-induced pressor response in pithed rats but demonstrates robust M3 antagonism, with an ED30 value of 0.36 mg/kg and an ID50 value of 2.4 mg/kg.[1] Additionally, YM-58790 free base exhibits strong inhibitory activity on bladder pressure during reflexly-evoked rhythmic contractions in rats.[1] |
| 存儲(chǔ)條件 | Shipping with blue ice. |
| 溶解度 | DMSO : 60 mg/mL (139.68 mM) |
| 關(guān)鍵字 | YM-58790 | YM 58790 | YM58790 |
| 相關(guān)產(chǎn)品 | Adiphenine hydrochloride | Nanofin | Arecoline hydrobromide | Forskolin | Pilocarpine Hydrochloride | CLOZAPINE N-OXIDE | Pilocarpine nitrate | Ribavirin | Adenine | Amitriptyline hydrochloride | Choline chloride | Propoxur |
| 相關(guān)庫(kù) | 神經(jīng)退行性疾病化合物庫(kù) | 經(jīng)典已知活性庫(kù) | 膜蛋白靶向化合物庫(kù) | 已知活性化合物庫(kù) |
Company Profile Introduction
Target Molecule Corp. (TargetMol) is a global high-tech enterprise, headquartered in Boston, MA, specializing in chemical and biological research product and service to meet the research needs of global customers.
TargetMol has evolved into one of the biggest global compound library and small molecule suppliers and a customer based on 40+ countries. TargetMol offers over 80 types of compound libraries and a wide range of high-quality research chemicals including inhibitors, activator, natural compounds, peptides, inhibitory antibodies, and novel life-science kits, for laboratory and scientific use. Besides, virtual screening service is also available for customers who would like to conduct the computer-aided drug discovery.
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United States- Since: 2011-01-07
- Address: 36?Washington?Street, Wellesley?Hills
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