Tyrphostin 8 NEW
| Price | $31 | $45 | $73 |
| Package | 5mg | 10mg | 25mg |
| Min. Order: | |
| Supply Ability: | 10g |
| Update Time: | 2025-05-02 |
Product Details
| Product Name: Tyrphostin 8 | CAS No.: 3785-90-8 |
| Purity: 99.86% | Supply Ability: 10g |
| Release date: 2025/05/02 |
Product Introduction
Bioactivity
| Name | Tyrphostin 8 |
| Description | Tyrphostin 8(4-Hydroxybenzylidenemalononitrile) is a potent GTPase inhibitor that inhibits EGFR kinase with an IC50 of 560 μM.Tyrphostin 8 inhibits protein serine/threonine calmodulin phosphatases (IC50=21 μM), enhances transferrin receptor-mediated transcytosis in Caco-2 cells, and increases the hypoglycemic effect of oral insulin-transferrin. hypoglycemic effect. |
| In vitro | Pretreated for 20 minutes at concentrations ranging from 10 to 100 μM, Tyrphostin 8 blocks Carbachol-initiated PKCδ tyrosine phosphorylation and ERK1/2 activation in parotid acinar cells[1]. Additionally, at concentrations of 10-100 μM, Tyrphostin 8 induces a rapid and substantial increase in the basal O2 consumption of parotid acinar cells[1]. Furthermore, at a concentration of 100 μM, Tyrphostin 8 reduces parotid ATP content by approximately 90%[1]. In another context, Tyrphostin 8 enhances the apical-to-basolateral transport of insulin-transferrin conjugate by promoting transferrin receptor-mediated transcytosis in filter-grown Caco-2 cell monolayers[2]. |
| In vivo | In Streptozotocin-induced diabetic rats, Tyrphostin 8 enhances the glucose-lowering effect of insulin-transferrin[2]. |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
| Solubility Information | DMSO : 50 mg/mL (293.82 mM), Sonication is recommended. |
| Keywords | Tyrphostin 8 | GTPase | EGFR |
| Inhibitors Related | Osimertinib | β-Glycerophosphate disodium salt pentahydrate | Lapatinib | Idoxuridine | Erlotinib hydrochloride | Tartaric acid disodium dihydrate | Cyclosporine | Erlotinib | Neratinib | Stearic acid | Genistein | Gefitinib |
| Related Compound Libraries | Anti-Colorectal Cancer Compound Library | Anti-Lung Cancer Compound Library | Bioactive Compound Library | Membrane Protein-targeted Compound Library | Tyrosine Kinase Inhibitor Library | Kinase Inhibitor Library | Angiogenesis related Compound Library | Inhibitor Library | Metabolism Compound Library | Immunology/Inflammation Compound Library | Bioactive Compounds Library Max | GPCR Compound Library |
Company Profile Introduction
Target Molecule Corp. (TargetMol) is a global high-tech enterprise, headquartered in Boston, MA, specializing in chemical and biological research product and service to meet the research needs of global customers.
TargetMol has evolved into one of the biggest global compound library and small molecule suppliers and a customer based on 40+ countries. TargetMol offers over 80 types of compound libraries and a wide range of high-quality research chemicals including inhibitors, activator, natural compounds, peptides, inhibitory antibodies, and novel life-science kits, for laboratory and scientific use. Besides, virtual screening service is also available for customers who would like to conduct the computer-aided drug discovery.
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United States- Since: 2011-01-07
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